摘要
目的探讨深圳市罗湖区15种人乳头瘤病毒(human papilloma virus,HPV)基因型的分子流行病学特点。方法选取2017年1月至2017年12月在深圳罗湖区人民医院妇科、体检科及社康中心接受HPV检测的22 496例女性患者作为研究对象,依据样本来源分为妇科组、体检组与社康组;按年龄分为5个年龄段:≤25岁,26~35岁,36~45岁,46~55岁,≥56岁。采用荧光PCR法检测15种高危型HPV(16、18、31、33、35、39、45、51、52、53、56、58、59、66、68型)感染情况。结果总体感染率为15.30%(3443/22 496),妇科组患者感染率为16.58%(2614/15 767),社康组感染率为14.03%(429/3058),体检组感染率为10.90%(400/3671)。高危型HPV感染年龄呈"U"形分布,≤25岁年龄段感染率最高,其次为≥56岁年龄段。总体感染率排名前五位的HPV基因型别依次为52、58、16、39、51型。各年龄段以单一感染最多见,多重感染以二重感染为主。结论深圳市罗湖区HPV感染亚型分布存在地区特异性,五个年龄段及三组不同风险人群HPV感染状况亦有差异。
Objective To clarify the molecular epidemiological characteristics of human papillomavirus(HPV)infection in the Luohu district of Shenzhen.Methods A total of 22 496 women,who received HPV detection in the department of gynecology,physical examination,and community health service center of Luohu People’s hospital from January 2017 to December 2017,were recruited as the subjects of this study.The subjects were grouped according age(less than 25 years old,26~35 years old,36~45 years old,46~55 years old and more than 56 years old.)and sample source(gynecological group,physical examination group and social health group).Fluorescence PCR was used to detect the infection rates of 15 high-risk HPV subtypes(HPV 16,18,31,33,35,39,45,51,52,53,56,58,59,66,68).Results The total HPV infection rate was 15.30%(3443/22496).HPV infection rate was 16.58%(2614/15767)for the women from the department of gynecology.For the women from the department of physical examination and community health service center,the infection rate was 10.9%(400/3671)and 14.03%(429/3058)respectively.The age distribution of the infection rate of high-risk HPV showed the shape of"U"-like.The highest HPV infection rate was found in women younger than 25 years old,followed by women over 56 years old.The top five HPV sub-genotypes with highest infection rate were HPV52,58,16,39,and 51,respectively.Infection with a single type of HPV was of predominant.Infection with two types of HPV was the primary among the infection with multiple HPV subtypes.Conclusion The distribution of HPV infection in Luohu district of Shenzhen shows regional characteristic,while the distribution of HPV genotypes is significant difference among women at different age groups,especially among women with high risk of HPV infection.
作者
许晓清
刘惠玲
张水兰
阚丽娟
刘小柳
莫红梅
Xu Xiaoqing;Liu Huilin;Zhang Shuilan;Kan Lijuan;Liu Xiaoliu;Mo Hongmei(Medical Laboratory of Shenzhen Luohu People's Hospital,Shenzhen 518001,China)
出处
《国际免疫学杂志》
CAS
2019年第3期257-262,共6页
International Journal of Immunology
基金
广东省深圳市医疗卫生三名工程项目(SZSM201601062).
关键词
人乳头瘤病毒
基因分型
感染率
Human papillomavirus
Genotypes
Infection rate
