摘要
目的探讨白细胞计数（WBC）和超敏c-反应蛋白（hs—CRP）与冠状动脉病变程度的关系及是否是冠心痛（CHD）的独立危险因素。方法用血细胞计数仪计数外围血白细胞总数，用胶乳免疫增强法测定112例经冠状动脉造影证实为CHD的患者及35例经冠状动脉造影证实无冠状动脉病变的对照组白细胞总数及血清hs—CRP，同时测定血清高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、餐后2h血糖水平。根据冠状动脉造影结果将CHD组分为1支、2支、3支病变组，观察白细胞总数及hs—CRP与冠状动脉病变的关系。同时调查年龄、性别、体质量指数（BMI）、血压、是否吸烟。结果cHD组白细胞总数、血清hs—CRP、HDL、LDL、餐后2h血糖与对照组比较差异有统计学意义（P〈0．01）。随着冠状动脉病变支数的增加，白细胞总数、血清hs-CRP水平逐渐增高。白细胞计数与体质量指数、腰围、血压、LDL．C、餐后2h血糖呈正相关（P〈0．01），与高密度脂蛋白呈负相关（P=0．000）。白细胞计数与冠状动脉病变程度呈正相关（r=0．400，P=0．000）。以白细胞计数水平为因变量的多元回归分析显示仅自变量BMI、hs-CRP、吸烟进入回归方程。结论炎性反应可能参与了冠状动脉病变的发生，白细胞计数水平与心血管病的危险因素如肥胖、餐后2h血糖、血压、低密度脂蛋白和吸烟有关。
Objective To investigate the relationship of high-sensitivity C-reactive protein （hs- CRP） and white blood cell count （WBC） with extent of coronary lesion and if it is an independent risk factor for coronary heart disease （CHD）. Methods One hundred and twelve patients with CHD confirmed by angiography and 35 patients without CHD （excluded by coronarography）. All patients measuring WBC, serum hs-CRP, serum high density lipoprotein （HDL-C）, low density lipoprotein （LDL-C）, and 2 h postprandial blood glucose levels by automated hematology analyzer （AHA） and latex immune enhancement act. According to the results of coronary angiography, CHD group was divided into 1, 2, 3 lesions, observed the relationship between WBC and hs-CRP with coronary artery lesions. Also investigated age, gender, body mass index （BMI）, blood pressure, smoking. Results There were significantly difference （P 〈 0. 01 ） between two groups in WBC, serum of hs-CRP, HDL-C, LDL-C, postprandial 2 h blood glucose levels. With the increase in the number of coronary arteries, the WBC count, serum hs-CRP levels gradually increased. White blood cell count and body mass index, waist circumference, blood pres- sure, HDL-C and LDL-C, 2-hour postprandial blood glucose were positively correlated （P 〈 0. 01 ）, they were negatively correlated with high density lipoprotein （P = 0. 000）. White blood cell count and severity of coronary lesions were positively correlated （r = 0. 400, P = 0. 000）. The level of white blood cell count as the dependent variable multiple regression analysis showed that the only variable, BMI, of hs-CRP, smoking into the regression equation. Conclusions Inflammatory response may be involved in the occurrence of coronary artery disease, white blood cell count levels are related with cardiovascular disease risk factors such as obesity, 2 h postprandial blood glucose, blood pressure, LDL and smoking.
出处
《中国实用医刊》
2012年第20期62-64,共3页
Chinese Journal of Practical Medicine
