摘要
目的考察地塞米松磷酸钠注射液在甘露醇注射液中的配伍稳定性。方法用HPLC方法监测地塞米松磷酸钠注射液与甘露醇注射液配伍后于20、25、30 C时自然光照射下24h内的含量变化,同时考察配伍液pH值与外观的变化情况。结果与配伍后0h比较,配伍后24h内外观、pH值、含量在25、30 C下无显著变化,在20 C时,保存1h就有少量结晶析出。结论建议地塞米松磷酸钠注射液不要与甘露醇注射液配伍后用于静脉滴注。
Objective To investigate the compatible stability of dexamethasone sodium phosphate injection in mannitol injection. Methods The content of dexamethasone sodium phosphate in the mixture of mannitol injection at 20, 25℃and 30℃ nder natural illumination within 24h by HPLC, and the pH and the appearance of the mixture were determined. Results No significant change was noted in the concentration of dexamethasoue sodium phosphate, the pH and the appearance of the mixture at 25℃ and 30℃ in 24 h, but there was some crystal at 20℃ after only 1 h. Conclusion The dexamethasone sodium phosphate injection should not be put in the mannitol injection for intravenous infusion.
出处
《中国医药指南》
2012年第24期54-55,共2页
Guide of China Medicine
