摘要
目的探讨糖尿病合并肺结核患者胸腔积液中肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)的检测价值,观察二者的关系及临床意义,以指导临床工作。方法选取我院诊治的88例糖尿病合并肺结核患者作为观察组,50例结核性胸腔积液患者作为对照组,抽取两组患者的胸腔积液,应用酶联免疫吸附实验(ELISA)检测两组中TNF-α的表达,应用免疫比浊法检测两组中hs-CRP的表达。结果 TNF-α和hs-CRP在观察组中的表达量明显高于对照组(均P<0.05),观察组中伴有糖尿病肾病患者TNF-α和hs-CRP的表达明显高于不伴有糖尿病肾病患者(均P<0.05)。相关分析显示观察组中TNF-α和hs-CRP的表达呈正相关(P<0.05)。结论 TNF-α和hs-CRP在糖尿病合并肺结核患者胸腔积液的表达明显升高,在疾病进展中可能具有重要价值。
Objective To detect the expresion of TNF-α and hs-CRP of pleural effusion in patients with diabetes and pulmonary tuberculosis, and investigate the clinical significance and relationship for directing clinical work. Methods 88 patients with debetes and pulmonary tuberculosis were observed as observation group, 50 patients with pulmonary tuberculosis were observed as control group. The expressions of TNF-α and hs-CRP of pleural effusion were detected in the two groups, the clinical characteristic were analyzed in observation group. Results The expression of TNF-α and hs-CRP were obviously higher in the observation group than in the control group （all P 〈 0.05）. The expression of TNF-α and hs-CRP were higher in the patients with diabetic nephropathy than patients without diabetic nephropathy in the observation group （all P 〈 0.05）. There were positively correlated between TNF-α and hs-CRP in the observation group （P 〈 0.05）. Conclusion The higher expression of TNF-α and hs-CRP can induce the formation of pleural effusion in patients with diabetes and pul- monary tuberculosis.
出处
《中国医药导报》
CAS
2012年第25期28-29,共2页
China Medical Herald
