摘要
胰腺癌是一种常见的消化系统恶性肿瘤，病死率极高，近年来其发病率有明显上升的趋势。由于胰腺癌解剖位置深在、早期症状隐匿、确诊率低，大多数临床确诊的胰腺癌患者已处于中晚期，失去了手术治疗的机会，预后极差。因此，提高胰腺癌的早期诊断率非常重要。肿瘤标志物对于肿瘤早期发现和筛查是一个重要的方法，若能找到并筛选出一种或一组胰腺癌肿瘤标志物，将有助于提高胰腺癌早期诊断率，改善预后。同时，南于肿瘤标志物相关研究技术的突飞猛进，当今的研究重点已经开始从基因水平过渡到蛋白质水平进行整体水平的研究。本文就近年来胰腺癌蛋白质肿瘤标志物的研究进展作一综述。
Pancreatic cancer is a commonly malignant gastrointestinal tumor with an obviously increasing incidence all over the world. Those patients without specific symptoms at early stage had mostly lost the opportunity of surgical therapy when pancreatic cancer was detected at advanced stage, and their prognosis is poor. Therefore, it is rather crucial to improve the early diagnosis of pancreatic cancer. Tumor marker is a considerable tool for early tumor detection and screening. It will help to improve the diagnostic rate of early pancreatic cancer and promote the prognosis of pancreatic cancer if we could find out tumor markers and screen one or a group of pancreatic cancer tumor markers.
出处
《国际外科学杂志》
2012年第8期546-549,共4页
International Journal of Surgery
基金
国家自然科学基金资助项目（No.81071985）
安徽省国际科技合作计划项目（No.1008010038）
安徽省科技攻关计划资助项目（No.11010402172）
安徽省教育厅自然科学研究项目（No.KJ2008A164）
关键词
胰腺肿瘤
肿瘤标志物
早期诊断
预后
Pancreatic neoplasms
Tumor markers
Early diagnosis
Prognosis
