摘要
目的探讨米索前列醇在预防剖宫产产后出血中的临床疗效。方法选取2009年10月～2011年7月在我院剖宫产产妇76例,随机分为治疗组和对照组各38例,其中治疗组在胎儿娩出后,直肠置入400μg米索前列醇,对照组子宫体肌注催产素20IU,比较两组产后2h和24h的出血量。结果两组产妇在术中的出血量无显著性差异,P>0.05,治疗组术后2h、24h的出血量均显著低于对照组,血红蛋白减少量也显著低于对照组,P<0.05;产后出血的产妇例数治疗组仅1例,占2.63%,显著低于对照组7例(18.42%),P<0.05,两组产妇产后出血的主要原因均为宫缩乏力。结论应用米索前列醇预防剖宫产产后出血,效果明显,能有效减少剖宫产产后的出血量和出血例数,增加产后子宫的收缩力度,且直肠给药副作用较小。
Objective To investigate the clinical efficacy of misoprostol in prevention from post- partum hemorrhage. Methods 76 cases in the hospital cesarean section from October 2009 to July 2011 were randomly divided into the treatment group of 38 cases and the control group of 38 cases. The treat- ment group was with rectum placed 400μg misoprostol after the baby was delivered. The control group was with uterus intramuscular oxytocin 20 IU. The post--partum bleeding 2h and 24h of the two groups were compared. Results The intraoperative blood loss during the surgery for the two groups of mothers was significant different （P 〉 0.05）. The hemorrhage volume 2 hours and 24 hours postoperative for the treatment group was significantly lower than the control group, the hemoglobin reduction was also sig- nificantly lower than the control group （P 〈 0.05）. The maternal cases of postpartum hemorrhage in the treatment group was only 1 case, accounting for 2.63%, was significantly lower than the control group of 7 cases （18.42%） （P 〈 0.05）. The main reason of the two groups of postpartum hemorrhage was u- terine contractions fatigue. Conclusions The effect is obvious, for the application of misoprostol to pre- vent postpartum hemorrhage can effectively reduce postpartum bleeding volume and the number of cases, increase efforts to postpartum uterine contraction, and has fewer side effect on rectal administration.
出处
《齐齐哈尔医学院学报》
2012年第16期2171-2172,共2页
Journal of Qiqihar Medical University
关键词
产后出血
米索前列醇
Postpartum hemorrhage Misoprostol
