摘要
目的探讨血必净注射液联合抗生素治疗细菌性肝脓肿的疗效。方法将61例细菌性肝脓肿患者随机分为联合组(31例)和对照组(30例)。所有患者均在B超引导下行经皮肝穿刺腔内抽脓术或置管引流术。术后对照组接受常规抗生素抗感染治疗;联合组在接受常规抗生素抗感染治疗的基础上加用血必净注射液50 mL+0.9%氯化钠注射液100 mL静脉滴注,1次/d,连用7 d。监测患者的体温、肝功能、血常规、血培养或脓液培养变化情况。结果联合组的治疗总有效率为96.8%,显著高于对照组的86.7%(P=0.027)。联合组的发热、腹痛、恶心呕吐的发生率分别为80.6%(25/31)、71.0%(22/31)、54.8%(17/31),均显著低于对照组的93.3%(28/30)、83.3%(25/30)、63.3%(19/30,P值均<0.05)。联合组的体温恢复正常、脓肿消失、细菌培养阴性及住院的时间均显著短于对照组(P值分别<0.05、0.01)。结论血必净注射液联合抗生素能显著提高细菌性肝脓肿患者的治愈率,缩短临床症状消失时间,值得临床推广应用。
Objective To investigate the effect of Xuebijing injection combined with antibiotics on bacterial liver abscess. Methods Sixty-one patients with bacterial liver abscess were randomly divided into combined group （n = 31 ） and control group （n = 30）. All the patients received percutaneous transhepatic puncture and drainage guided by B ultrasound. Patients in the control group were treated by antibiotics routinely, while patients in the combined group recceived antibiotics plus intravenous drip of Xuebijing injection （Xuebijing injection 50 mL added in 0.9% sodium chloride injection 100 mL, once a day, infused successively for 7 d）. Temperature, liver function, routine blood test and blood culture or pus culture were monitored. Results The total effective rate of the combined group was significantly higher than that of the control group （96.8% vs. 86.7%, P = 0. 027）. The incidence of complications such as fever, abdominal pain, nausea and vomit in the combined group were 80. 6% （25/31）, 71.0% （22/31） and 54.8% （17/31）, respectively, which were significantly lower than those in the control group （93.3 % [28/30], 83.3% [25/30] and 63.3% [19/30], all P 〈 0.05）. Temperature recovery time, abscess healing time, negative bacterial culture duration and hospital stay in the combined group were significantly less than those in the control group i P〈0. 05 or 0.01）. Conclusion Xuebijing injection combined with antibiotics can significantly increase the curative rate and shorten the time of clinical symptom in patients with bacterial liver abscess. Therefore, it is worth popularzing in clinical practice.
出处
《上海医学》
CAS
CSCD
北大核心
2012年第7期609-612,共4页
Shanghai Medical Journal
关键词
血必净注射液
细菌性肝脓肿
穿刺引流
抗生素
疗效
Xuebijing injection
Bacterial liver abscess
Puncture and drainage
Antibiotics
Therapeuticeffect
