摘要
目的:探讨抗癫痫药左乙拉西坦(LEV)对癫痫患儿骨代谢的影响。方法:选择2008年1月—2010年2月期间在唐山市妇幼保健院首发初诊的原发性癫痫患儿30例,予口服LEV治疗。于治疗前和治疗后6个月、12个月分别测定骨密度(BMD)、骨碱性磷酸酶(BAP)、血钙(Ca2+)、血磷(P)、血中碱性磷酸酶(ALP)。对照组为30例未治疗的原发性癫痫患儿,同期检测上述指标。对上述骨代谢指标进行评价。结果:左乙拉西坦治疗前后骨代谢指标差异无显著性(P>0.05)。左乙拉西坦治疗前、治疗后6个月、12个月BMD、BAP、Ca、P、ALP与对照组比较差异无显著性(P>0.05)。结论:短期服用左乙拉西坦(LEV)对癫痫患儿骨代谢无明显影响。
OBJECTIVE To assess the bone metabolism in epileptic children treated with levetiracetam（LEV）.METHODS The treatment group was selected from 30 case of idiopathic epilepsy children who had been treated with levetiracetam（LEV） in Maternal and Child Health Hospital of Tangshan from January 2008 to February 2010.Bone mineral density（BMD）,bone alkaline phosphate（BAP）,serum calcium（Ca^2＋）,serum phosphorum（P）,alkaline phosphate（ALP）were detected before LEV treatment and 6,12 months after LEV treatment.Thirty age and sex-matched idiopathic epilepsy children with infrequent seizures and without treatment were used as controls.RESULTS（1）There were no significant differences in bone metabolism indices,such as BMD,BAP,Ca,P,ALP between the treatment group before LEV treatment and 6,12 months after LEV treatment and control group（P〉0.05）.（2）There were no significant differences in bone metabolism indices between before and after treatment with LEV（P〉0.05）.CONCLUSION Bone metabolism of children from four to fourteen years old with epilepsy may not be influenced by antiepileptic drugs levetiracetam in the short term.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第17期1379-1381,共3页
Chinese Journal of Hospital Pharmacy
关键词
左乙拉西坦
骨代谢
癫痫
儿童
levetiracetam bone metabolism
epilepsy
child
