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脂肪因子内脂素与缺血性脑卒中的相关性研究 被引量:5

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摘要 目的探讨脂肪因子内脂素与缺血性卒中(IS)的相关性。方法纳入42例诊断为IS的患者,同时从门诊随机抽取40例健康人群作为对照组。应用非条件Logistic回归分析进行多因素分析。结果单因素分析结果表明:两组间内脂素、男性、高血压病史、糖尿病史、冠心病病史、吸烟史、总胆固醇(TC)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)差异存在显著性;其中,内脂素、男性、高血压病史、糖尿病史、冠心病病史、吸烟史、TC、LDL-C与IS的发生呈正相关;HDL-C与IS的发生呈负相关。进一步行多因素分析结果表明:内脂素、冠心病史、糖尿病史是IS发生的独立危险因素。结论内脂素是IS发生的独立危险因素,其可能作为炎性因子及促炎症因子参与血管炎性反应的发生,同时引起血管内皮受损等作用而导致IS发生风险的增高。
作者 宋宏毅
出处 《中国医刊》 CAS 2012年第9期61-62,共2页 Chinese Journal of Medicine
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