摘要
目的:观察复心煎对体外循环(CPB)患者围术期免疫指标(T淋巴细胞亚群,血清IgG、IgA、lgM、C3、C4,WBC、N、L计数)的干预效果。方法:CPB心内直视瓣膜置换患者90例随机均分为3组:术前、后干预组(A、B组)、对照组(C组)。术前第7天、CPB开始前、停机即刻、术后第1、3、8天检测各组免疫指标。结果:各组CPB后T淋巴细胞亚群均减少,术后第1、3天降低明显(P<0.05),术后第8天A、B组部分恢复至术前水平;A、B组减少程度均较轻(P<0.05)。CPB后血清IgG、IgA、lgM、C3、C4减少,术后第1天降低最明显(P<0.05),第8天不同程度恢复;A组上述指标较好,第8天A、B组恢复均较C组好(P<0.05)。WBC及N计数在停机即刻明显升高,后下降,但到第8天仍未恢复至术前水平,与CPB开始前比较,差异有统计学意义(P<0.05);L计数停机即刻及术后第1天明显减少,后逐渐回升,第8天未恢复至术前水平,与CPB开始前比较,差异有统计学意义(P<0.05),与C组比较,A、B组恢复好(P<0.05),停机即刻A组减少程度较C组轻(P<0.05)。结论:复心煎可有效干预CPB手术患者免疫功能紊乱。
Objective： To observe intervention effect of Fuxinjian on patients＇ immune indexes （T lymphocyte subsets, serum IgG, IgA, lgM, C3, Ca, leukocyte, neutrophil, total lymphocyte count） during perioperative period of cardiopulmonary bypass （CPB） operations. Methods： 90 patients who needed CPB in open heart valve replacement surgery were divided equally into 3 treatments according to the completely randomized design： Fuxinjian preoperative intervention group （A group）, Fuxinjian postoperative intervention group （B group）, control group （C group）. Above-mentioned indexes in peripheral venous blood of each patient were measured in the the seventh day, before operation, just at the begin and end of CPB, the first, the third and the eirhth day after operations. Results： T lymphocyte subsets were decreased significantly after all CPB operations, especially within 1 to 3 clays （P〈0.05）, and returned to the preoperative level partly until eight days after operations in A and B groups. Before CPB operation, the levels of above indexes were better in the A group. The degrees of reduction were lighter after CPB operations in both of the A and B groups （P〈0.05）. The levels of serum IgG, IgA, lgM, C3, C4 were significantly decreased, especially on the first postoperative day, and returned to the preoperative level partly on the eighth day after operations in both of the first and second groups. Before CPB operations, the levels of above indexes were better in the A group, showed better recovery on the eighth day after operations in the A and B groups than the C groups. The WBC and neutrophils count increased significantly just at the end of CPB, and then decreased gradually, but which were still higher the eighth day after operations. There was no significant difference as compared with that of the C group. The lymphocyte count was decreased significantly on the first postoperative day, and then rose gradually, but which was still higher on the eighth day after operation. There was signif
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第9期2478-2482,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
江苏省中医药局科技项目(No.LB09114)~~
关键词
复心煎
体外循环
免疫功能紊乱
Fuxinjian
Cardiopulmonary bypass
Resistance mechanism disorders
