摘要
目的观察益气活血祛风汤对慢性荨麻疹患者二胺氧化酶(diamine oxidase,DAO)及免疫球蛋白IgE的影响。方法选择2009年7月—2010年12月陕西省中医院皮肤科门诊慢性荨麻疹患者85例,随机分为治疗组(50例)和对照组(35例),另选取15名健康者为健康组。治疗组口服益气活血祛风汤,每天1剂,分早晚2次;对照组口服肤痒颗粒,6g/次,3次/天。两组均治疗8周。观察两组治疗后及停药后2个月的有效率。检测各组治疗前后血清DAO、IgE水平。结果治疗组治疗后痊愈率20例(44.0%)及停药2个月有效率(62.0%)均高于对照组分别为7例(20.0%),31.4%,差异有统计学意义(P<0.05)。两个患者组治疗前DAO治疗组:(6.9±1.8),对照组:(6.5±1.8)明显高于健康组(1.1±0.4),差异有统计学意义(P<0.05);与本组治疗前比较,两个患者组治疗后DAO、IgE阳性率均降低,治疗组低于对照组,差异均有统计学意义(P<0.05)。结论益气活血祛风汤能改善慢性荨麻疹患者症状,改善胃肠黏膜屏障功能和免疫功能。
Objective To observe effects of Yiqi Huoxue Qufeng Decoction （YHQD, with the actions of splenishing qi, activating blood, and dispelling wind） on diamine oxidase （DAO） and immunoglobulin E （IgE） of patients with chronic urticaria. Methods Eighty-five chronic urticaria patients from the clinics of dermatology, Shaanxi Hospital of Traditional Chinese Medicine were randomly assigned to the treatment group （50 cases） and the control group （35 cases）. Besides, another 15 healthy volunteers were recruited as the healthy group. Pa- tients in the treatment group took YHQD, one dose daily, once in the morning and once in the evening. Patients in the control group took Fuyang Granule （ FYG）, 6 g each time, three times daily. The therapeutic course for the two groups was 8 weeks. The effective rates of the two groups were observed after treatment and 2 months after quitting treatment. The levels of DAO and IgE were observed in the three groups before and after treatment. Results The post-treatment recovery rate （20 cases, 44.0%） and the effective rate 2 months after quitting treat- ment （62.0%） were higher in the treatment group than in the control group （7 cases, 20. 0% ; 31.4% ） with sta- tistical difference （P〈0.05）. The DAO level in the two treatment groups （6.9 ＋1.8 in the treatment group and 6.5 ＋1.8 in the control group） was obviously higher than that in the healthy group （1.1 ＋0.4）, showing statisti- cal difference （P〈0.05）. The post-treatment DAO and IgE both decreased in the treatment group and the con- trol group when compared with before treatment in the same group. Those were lower in the treatment group than in the control group with statistical difference （ P 〈 0.05）. Conclusion YHQD could improve the symptoms of chronic urticaria patients, ameliorate the intestines mucosa barrier function and the immunity.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2012年第9期1216-1218,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
陕西省中医药管理局资助项目(No.jc92)
