摘要
目的探索在没有新鲜供体角膜供穿透性角膜移植的情况下，观察以改良甘油长期冷冻保存的角膜行桥式穿透性角膜移植的效果。方法角膜大面积溃疡并穿孔病例共10例10只眼，溃疡直径5-8mm，穿孔直径2-4mm。以改良甘油冷冻保存法保存2个月至2年的角膜进行桥式穿透性角膜移植，术后观察植片透明情况、角膜上皮愈合时间、眼压及并发症等。结果术后随访12～24个月，10例患者溃疡均治愈无复发，植片呈半透明状，角膜植片上皮完全修复时间（10．2±3．6）d，植片水肿完全消退时间（30．7±6．8）d，眼压均正常。术后视力指数朋艮前～0．25。结论在没有新鲜供体角膜的情况下，以改良甘油冷冻保存法长期保存的角膜进行桥式穿透性角膜移植治疗重症角膜溃疡穿孔，能保住眼球和部分视力，成功率较高。
Objective To study the clinical effects of bridge-type penetration keratoplasty （BPK） using glycerol cryopreserved corneas for severe corneal perforation in the absence of fresh donor cor- nea for penetrating keratoplasty. Methods Ten patients （10 eyes） of severe corneal ulcer with perfo- ration were received bridge-type penetrating keratoplasty with corneas preserved for 2 months to 2 years by improved cryopreservation with glycerol. The diameter of all corneal ulcers were 5-8mm, the diameter of perforations were 2-4mm. The transparency of the grafts, corneal epithelial healing time,intraocular pressure （lOP） and complications were observed after operation. Results The postop- erative follow-up of 12 months to 2 years revealed that all corneal ulcers had no recurrence, grafts were translucent, corneal epithelium was fully restored in 10.2±3.6 days,graft edema dissipated in 30.7±6.8 days, IOP were all normal. The vision ranged from finger counting to 0.25. Conclusions In the absence of fresh donor cornea, the operation of bridge-type penetration keratoplasty can be used successfully with the corneas preserved by improved long-term cryopreservation with glycerol in the clinical emergency treatment for severe corneal ulcer perforation. The grafts can keep transpar- ency in a long time,so that it can keep the eyes to avoid enucleation and can enhance visual acuity.
出处
《中国实用眼科杂志》
CSCD
北大核心
2012年第9期1107-1110,共4页
Chinese Journal of Practical Ophthalmology
基金
南京军区“十一五”医药卫生基金资助课题（06MA105）
关键词
角膜穿孔
重症角膜溃疡
角膜移植
桥式
低温冷冻
角膜保存
甘油
Corneal perforation
Severe corneal ulcer
Bridge-type keratoplasty
Freezing-pre- served
Corneal preservation
Glycerol
