摘要
目的通过分析手足口病的临床特征、流行病学以及病原学特点,为相关疾病的预防、诊断及治疗提供临床及实验室依据。方法回顾性分析本院2009～2011年住院治疗的2411例患儿的临床病例资料,从患儿咽拭子中分离病原并进行鉴定分析。结果本组病例中散居儿童1392例(57.74%),显著多于群居儿童(P<0.05)。本组患儿的主要临床症状及体征表现为发热和皮疹,皮疹部位以手、足、口、臀和膝等为主。本组病例中的2411例患儿全部出现皮疹;其中1845例患儿有发热症状,占76.52%。本组患儿给予常规抗病毒和对症治疗后,2404例(99.7%)治愈。本研究中重症病例279例(11.6%);住重症ICU病房者29例,占1.2%;死亡7例,占0.29%。本组病例均行病毒分离及鉴定分析,有1308例(54.3%)检测出病毒;其中279例重症病例分离出EV71186株,柯萨奇病毒A1618株,其他肠道病毒32株。结论手足口病好发于散居儿童,感染EV71后易发展为重症手足口病且病死率高,而早期发现、早期治疗可提高其生存率。
Objective To investigate the clinical features, epidemiological and etiology characteristics of hand, foot and mouth disease （HFMD）, and the experience or lessons for the treatment of HFMD. Methods The clinical features of 2411 patients with HFMD of hospitalized patients in our hospital from 2009 to 2011 were analyzed, retrospectively; pathogens were separated from swab of them and then analyzed. Results The scattered children were 1392 （57.74%） cases, which were significantly more than gregarious children. The main clinical manifestations of the patients were fever and rash, and the rash occurred on hands, feet, mouth, buttocks and knees. All of 2411 children with HFMD had skin rashes, and 1845 cases （76.52%） with fever. After anti-virus therapy and symptomatic treatment, 2404 cases （99.7%） were cured. There were 279 severe cases, including 29 cases accepted in ICU, among whom 7 children died. The pathogen of these patients with HFMD were all detected in their swab and then identified. And virus was separated from 1308 patients （54.3%）. Total of 186 EV71 strains, 18 Coxsackievirus A16 strains （6.45%） and other 32 enterovirus strains were found in 279 severe cases. Conclusions The hand, foot and mouth disease often occured in predilection scattered children. Children with EV71 virus infection develop into severe cases easily, and with a high mortality. We could improve curative effect and survival rate through early detection and treatment.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2012年第4期57-60,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
手足口病
诊断
流行病学
Hand, foot and mouth disease
Diagnosis
Epidemiology
