摘要
目的观察喉鳞癌组织中凋亡抑制因子Livin蛋白的表达,探讨其在喉癌发生、发展中的作用及与其预后的关系。方法采用免疫组化SP法检测117例喉鳞癌组织和20例正常舌腭弓黏膜组织中Livin蛋白的表达,结合临床及随访资料,分析其与各临床病理因素及预后的关系。结果①喉癌组织中Livin蛋白阳性表达率为61.5%(72/117),在正常对照组中Livin蛋白呈阴性表达,差别具有统计学意义(P<0.05);②Livin蛋白在喉鳞癌组织中阳性表达率与病程、临床分期及淋巴结转移有关(P<0.05),与年龄、临床分型和组织分化程度无关(P>0.05);③Cox回归模型多因素分析结果示临床分期晚、有淋巴结转移和Livin蛋白阳性表达是肿瘤复发的独立危险因素。结论 Livin蛋白可能在喉鳞癌的发生、发展中起一定作用,其阳性表达可能在一定程度上提示喉癌的预后。
Objective To investigate the expression of Livin in laryngeal squamous cell carcinoma （LSCC） and its associations with carcinogenesis, progression and prognosis. Methods Immunohistochemistry was performed to detect the expression of Livin in 117 cases of LSCC and 20 controls of normal mucous membrane of palatoglossal pillar. Comparisons of the resuhs with the clinical and follow - up data were conducted. Results ① Livin expression was detected in 61. 5% （72/117） cases of LSCC and negative in all normal mucous membrane of palatoglossal pillars. A significant difference was observed between the two groups （ P 〈 O. 05 ）. ②The positive rate of Livin expression was markedly associated with the course of disease, clinical stage and lymph node metastasis status respectively （ P 〈 O. 05 ）. However, no associations of Livin expression with age, position and histological grades were observed （ P 〉 O. 05 ）. ③ Multivariate cox proportional hazards model analysis demonstrated that clinical stage, lymph node metastasis and expression of Livin in LSCC were independent predictive factors in laryngeal cancer recurrence. Conclusion The elevated expression of Livin in LSCC might play an important role in the carcinogenesis of LSCC and its progression. Elevated expression of Livin in LSCC may predict the prognosis.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2012年第4期253-257,共5页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
贵州省科技厅资助项目
项目编号:E2009-40
关键词
喉鳞状细胞癌
LIVIN蛋白
免疫组化
Laryngeal neoplasm
Carcinoma, squamous cell
Livin protein
Immunohistochemistry
