摘要
目的:考察氟脲苷在0.9%氯化钠注射液和5%葡萄糖注射液中的稳定性。方法:观察在室内、室内避光和低温条件,24 h内氟脲苷在氯化钠和葡萄糖注射液的外观、pH变化;观察配伍液中不溶性微粒的变化,测定氟脲苷的含量变化。结果:配伍液在24 h内无浑浊、沉淀、气体产生,颜色、pH、不溶性微粒数等无明显变化,在三种不同条件下,氟脲苷在0.9%氯化钠注射液和5%葡萄糖注射液中的含量24 h内无明显变化。结论:在实验条件下,注射用氟脲苷在0.9%氯化钠注射液和5%葡萄糖注射液中24 h内对光和温度均稳定。
Objective ： To observe the compatibility of foloxuridin mixed with 0.9% sodium chloride and 5% glucose for injection. Method： The changes in appearance, particles and pH of the mixture within 24h at ambient temperature with or without lighting and at low temperature were observed. The concentration of foloxuridin was determined by HPLC. Result： There was no evident change in the appearance and color, and no gas, precipitation or turbid was shown. No significant change in the particles, pH and the content of foloxuridin within 24h as well. Conclusion： foloxuridin injections in 0.9% sodium chloride and 5% glucose injections are stable within 24h.
出处
《中国药师》
CAS
2012年第7期1002-1004,共3页
China Pharmacist
