摘要
目的:探讨妊娠期糖尿病患者血清C-反应蛋(CRP)、白细胞介素6(IL-6)水平变化及其与胰岛素抵抗、血脂的关系。方法:采用放射免疫法测定妊娠24～28周无孕前肥胖的30例妊娠期糖尿病孕妇(GDM组)和30例正常妊娠晚期孕妇(正常妊娠组)的空腹血清IL-6水平,同时测定两组孕妇血清CRP、空腹血糖(FBS)、胰岛素(FINS)、C肽、总胆固醇(TG)和甘油三酯(TC)水平,并计算孕前体重指数(BMI)、胰岛素抵抗指数(HOMA-IRI)以评价胰岛素抵抗程度。结果:两组孕妇空腹血清CRP、IL-6、FBS、F INS、C肽、HOMA-IRI、TG水平及孕前BMI比较,差异有统计学意义(P<0.01或P<0.05),而血清TC水平比较差异无统计学意义(P>0.05);CRP和IL-6的水平分别与HOMA-IRI、TG呈正相关性(r=0.886,0.792,P<0.05;r=0.685,0.767,P<0.05),与TC无相关性(P>0.05)。结论:在无孕前肥胖状况下,妊娠期糖尿病患者血清CRP、IL-6水平的升高与胰岛素抵抗、血脂指标异常有关。
Objective： To explore the changes of serum C -reactive protein （CRP） and interleukin -6 （IL- 6） levels in patients with gestational diabetes mellitus （ GDM ） and their relationships with insulin resistance and blood lipids. Methods： Radioimmunoassay （RIA） was used to detect the serum levels of fasting IL -6 in 30 pregnant women with GDM （GDM group） and 30 normal pregnant women during the third trimester of pregnancy （ normal pregnancy group） ; all the pregnant women in the two groups had no pregestational obesity and they were at 24 -28 gestational weeks; the levels of serum CRP, fasting blood glucose, insulin, C peptide, total cholesterol, and triglyceride in the two groups were measured during the same time; pregestational body mass index （BMI） and insulin resistance index were calculated to evaluate the degree of insulin resistance. Results： There was statistically significant difference in the levels of fasting CRP, IL -6, fasting blood glucose, insulin, C peptide, insulin resistance index, total cholesterol, and pregestational BMI between the two groups （P 〈 0. 01 or P 〈 0. 05）, but there was no statistically significant difference in the level of serum triglyceride between the two groups （ P 〉 0. 05） . there was a positive correlation between CRP level and insulin resistance index, total cholesterol （γ= 0. 886, T = 0. 792, P 〈 0. 05） ; IL - 6 level was positively correlated with insulin resistance index and total cholesterol （ γ = 0. 685, γ = 0. 767, P 〈 0. 05） ; but there was no correlation between CRP, IL - 6 and triglyceride （ P 〉 0.05 ） . Conclusion： On the condition of without pregestational obesity, the increases of serum CRP and IL - 6 were correlated with insulin resistance and abnormalities of blood lipids indexes in patients with GDM.
出处
《中国妇幼保健》
CAS
北大核心
2012年第25期3892-3894,共3页
Maternal and Child Health Care of China
关键词
C反应蛋白
白细胞介素6
胆固醇
甘油三酯
妊娠期糖尿病
胰岛素抵抗
C - reactive protein
Interleukin - 6
Cholesterol
Triglyceride
Gestational diabetes mellitus
Insulin resistance
