摘要
目的研究肝再生磷酸酶-3(PRL-3)在非小细胞肺癌(NSCLC)的表达及意义。方法采用免疫组化法检测25例对照组和51例NSCLC患者PRL-3表达水平并进行分析比较。结果 PRL-3在对照组、肺癌组的阳性表达率分别为12.00%和74.51%(P<0.05);PRL-3的表达与非小细胞肺癌有无淋巴结转移及临床分期有关(P<0.05),与年龄、性别、病理类型无关(P>0.05)。结论 PRL-3表达与非小细胞肺癌的发生发展有一定的关系,PRL-3检测可作为判定非小细胞肺癌浸润及转移程度的一个生物学指标。
Objective To study expression of phosphatase of regenerating liver-3 （ PRL-3 ） in non- small cell lung cancer （NSCLC） and significance. Methods By immunohistochemical method in 25 cases of the control group in 51 eases of NSCLC and PRL-3 expression level comparison and analysis. Results PRL-3 in the control group, the positive rate in lung cancer group were 12% and 74. 51% （P 〈 0. 05）. PRL-3 expres- sion in non small cell lung cancer with lymph node metastasis and the clinical stage （ P 〈 0. 05）, age, gender, pathologic types （ P 〉 0. 05）. Conclusion PRL-3 expression in non small cell lung cancer occurrence and de- velopment have a certain relationship, PRL-3 testing can be used as non-small cell lung cancer invasion and me- tastasis of a biological indicator.
出处
《中国实用医药》
2012年第21期42-43,共2页
China Practical Medicine
