摘要
目的:观察阿立哌唑与喹硫平治疗老年精神分裂症的疗效及安全性。方法:回顾性分析我院2009年2月～2011年11月精神科收治的84例老年精神分裂症患者临床资料,随机分为两组,其中A组42例采用阿立哌唑治疗,B组42例采用喹硫平治疗。治疗8周后,采用PANSS量表评定疗效,采用TESS评定从患者治疗前后的体重指数、血糖、血脂指标差异评定不良反应。结果:两组疗效相当无显著性差异(P>0.05);B组采用喹硫平治疗后患者血糖水平升高,A组采用阿立哌唑对患者血糖影响不明显,B组血清总胆固醇水平升高,A组患者胆固醇影响不明显,两组甘油三酯水平均有升高。A组阿立哌唑组不良反应较B组喹硫平组轻,其中震颤、静坐不能、肌强直等发生率低于B组(P<0.05)。结论:阿立哌唑与喹硫平治疗老年精神分裂症疗效相当,阿立哌唑不良反应较喹硫平少,能有效改善患者阴、阳性症状及认知功能,利于治疗效果的巩固。
Objective：To observe efficacy and side effects of Aripiprazole and Quetiapine in the treatment of geriatric schizophrenic patients. Methods：A retrospective analysis was performed on the clinical data of 86 geriatric schizophrenic patients admitted from February 2009 to November 2011 in our hospital. Patients were randomly assigned to receive Aripiprazole （n = 42） or Quetiapine （n = 42） treatment. Efficacy and side effects were measured by Positive and Negative Syndrome Scale （PANSS） and Treatment Emergent Symptom Scale （TESS）, Body Mass Index, Blood Glucose and Blood Lipids before and after treatments of 8 weeks. Results： No significant difference of efficacy was found between two groups （ P 〉 0.05 ）. The Quetiapine group showed increased blood glucose level and serum total cholesterol level after treatment while the Aripirazole group had no significant change. Triglyceride level was increased in both groups. The Aripirazole group had lower incidence rates of tremor, akathisia and rigidity （P 〈 0.05）. Side effects were less severe in the Aripirazo｜e group than in the Quetiapine group. Conclusions： Aripiprazole and Quetiapine had equally good efficacy in the treatment of geriatric schizophrenic patients. Aripiprazole has less side effects than Quetiapine and can improve positive and negative symptoms and cognitive function effectively. Aripiprazole is good for consolidating treatment effects.
出处
《中国民康医学》
2012年第15期1826-1827,共2页
Medical Journal of Chinese People’s Health
