摘要
通过恒电流电解一步法在玻碳电极表面制备了聚(3,4-乙烯基二氧噻吩)/碳纳米管复合膜,实验结果表明,该复合膜修饰电极综合了聚(3,4-乙烯基二氧噻吩)(PEDOT)和碳纳米管(CNTs)两者的优点,对8-羟基-2'-脱氧鸟嘌呤核苷(8-OH-dG)的氧化具有明显的增强作用,较好地抑制尿酸的干扰,而且具有很好的重现性和稳定性.在0.1 mol/L pH 9.0的磷酸盐缓冲溶液(PBS)中,8-OH-dG的氧化峰电流与其浓度在0.014～14.0μmol/L和14.0～56.0μmol/L两个范围内成良好的线性关系,检出限可达35 nmol/L(S/N=3).
The poly（3, d-ethylenedioxythiophene）/carbon nanotubes （CNTs） composite film was prepared on the glassy carbon electrode surface by one-step galvanostatic deposition and used for the study of the electrochemical behavior of 8- hydroxy-2＇-deoxyguanosine （8-OH-dG）. The experimental results showed that the hybrid film can combine the advanta- ges of conductivity of PEDOT and the unique electronic performance of CNTs and effectively enhance the adsorption and electroc, hemical oxidation of 8-OH-dG. Moreover, this proposed hybrid fihn modified electrode also showed excellent re- producibility and stability in the experiment. In 0. 1 mol/L pH 9. 0 phosphate buffer solution, the oxidative peak currents of 8-OH-dG had two good linear relationships with its concentration in 0. 014 - 14 μmol/L and 14 -56 μmol/L, with the detection limit of 35 nmol/L （ S/N = 3 ）.
出处
《南京师大学报（自然科学版）》
CAS
CSCD
北大核心
2012年第2期66-71,共6页
Journal of Nanjing Normal University(Natural Science Edition)
基金
国家自然科学基金(21075059)
山东省"泰山学者"建设工程专项经费资助
