摘要
目的探讨伽马刀放射治疗对原发性三叉神经痛患者生存质量的影响。方法将56例原发性三叉神经痛患者分为伽马刀放射治疗组(21例)及常规治疗组(35例)。两组患者均于治疗前、治疗(或放射治疗)后第3～6个月随访,由专人运用简化McGill疼痛量表(short-form of McGill pain questionnaire,SF-MPQ)、综合医院焦虑抑郁量表(hospital anxiety and depression scale,HAD)、匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)等问卷进行测试。观察患者疼痛改善、服药、神经心理及睡眠情况。结果治疗后,伽马刀放射治疗组疼痛评定指数(pain ratingindex,PRI)、视觉模拟评分法(visual analogue scale,VAS)与现时疼痛强度(present pain intensity,PPI)等得分(分别为4.24±0.40,1.29±0.10,1.22±0.04)显著优于常规治疗组(分别为21.90±1.41、4.49±0.33、2.37±0.07);平均每天卡马西平用量明显少于常规治疗组;PSQI总分及7个因子得分、HAD得分优于常规治疗组;PSQI总分及PRI、VAS、PPI得分与焦虑、抑郁得分呈正相关。结论伽马刀放射治疗是对治疗PTN有效,可以改善患者疼痛及其相关睡眠障碍、抑郁、焦虑等症状,提高患者的生存质量。
Objective To study the effect of γ-knife radiotherapy on the quality of life of patients with primary trigeminal neuralgia（PTN）.Methods A total of 57 PTN patients were divided into γ-knife radiotherapy treatment group（21 cases） and conventional treatment group（35 cases）.The short-form of McGill pain questionnaire（SF-MPQ）,Pittsburgh sleep quality index（PSQI） and hospital anxiety and depression scale（HAD） was utilized to investigate the patients＇ quality of life,including pain relief,drug use,neuropsychology and sleep status before therapy and 3-6 months after therapy.Results The scores of pain rating index（PRI）,visual analogue scale（VAS） and present pain intensity（PPI） of the γ-knife radiotherapy treatment group after treatment（4.24±0.40,1.29±0.10 and 1.22±0.04 respectively） were better than those of the conventional treatment group（21.90±1.41,4.49±0.33 and 2.37±0.07 respectively）.Compared with the control group,the mean dosages of Carbamazepine utilization every day of the γ-knife radiotherapy group were less;the total PSQI scores and the 7 factor scores were higher and the HAD scores were lower.The total PSQI scores and the PRI,VAS and PPI factor scores were positively correlated with the anxiety and depression scores.Conclusion γ-knife radiotherapy is effective in treating PTN,can improve the symptoms of the patients including pain,sleep disorder,depression and anxiety,and enhance their quality of life.
出处
《华南国防医学杂志》
CAS
2012年第4期342-344,共3页
Military Medical Journal of South China
