摘要
目的 探讨脑膜瘤血管生成与脑膜瘤瘤周水肿、复发和预后的关系。方法 对 5 7例脑膜瘤的 CT、 因子相关抗原抗体免疫组化染色和病理学资料以及 32例脑血管造影结果进行脑膜瘤微血管密度 (MVD)与病理类型、瘤周脑水肿及患者术后复发率、生存期之间的关系研究。结果 5 7例脑膜瘤患者平均微血管密度 (MVD)为 34 .5。其中良性、不典型性和恶性脑膜瘤微血管密度分别为 2 6 .8± 9.3、41.2±12 .9和 5 2 .7± 14.6 ,三种病理类型 MVD均有显著差异 (P<0 .0 1) ;中、重度脑水肿组其瘤组织 MVD分别为 (39.4±11.3和 47.9± 12 .6 )与轻度和无脑水肿组 MVD(30 .1± 9.7和 2 5 .2± 8.5 )相比有显著性差异 (P<0 .0 5 ) ;有颈外动脉供血或肿瘤染色者易发生瘤周水肿。 MVD≥ 34 .5组三年 ,五年复发率均高于 MVD<34 .5组 (P<0 .0 5 ) ,且前者五年生存率明显低于后者 (P<0 .0 5 )。结论 脑膜瘤微血管密度可作为判断肿瘤侵袭力及评价患者术后复发和预后的良好指标。
Objective To study the relations between angiogenesis with peritumoral edema, recurrence and prognosis in patients with meningiomas. Methods CT and the immunohistochemical study of factor Ⅷ related antigen antibody and pathological data of 57 cases of meningiomas and the cerebral angiography data of 32 cases were studied. The relation between the microvessel density (MVD), tumor pathological feature, peritumor edema found in CT and the patients' prognosis were analysed. Results All cases of meningioma has the mean microvessel density (MVD) of 34 5 MVD in atypical and malignant meningioma were (41 2±12 9) and (52 7±14 6), respectively, far exceeded that in benign meningioma (26 8±9 3) ( P<0 01 ). MVD in cases with perifocal reaction (25 2±8 5) and slight edema (30 1±9 7) were significantly lower than those of medium edema (39 4±11 3) and severe edema (47 9±12 6) ( P<0 05 ). The tumors which had rich blood supply, especially those supplied by external carotid artery and stained in the cerebral angiography or DSA were often accopanied by edema. Patients with MVD more than 34 5 have higher 3,5 year recurrent rates and lower 5 year survival rates than those cases with MVD less than 34 5 ( P <0 05). Conclusion MVD in meningioma is a valuable criterium in judging the invasive power of the tumor and in evaluating of its recurrence and prognosis.$$$$
出处
《肿瘤》
CAS
CSCD
北大核心
2000年第4期273-275,共3页
Tumor
基金
全军九五科研基金!( 96-M-14 1)
河南省杰出青年科学基金
