摘要
目的寻找导致脑膜瘤瘤周水肿的相关因素 ,探讨瘤周水肿产生的机制。 方法依据影像学资料对18例患者的瘤周水肿程度作半定量评分 ,用Logistic回归分析肿瘤大小、病理类型、肿瘤包膜是否完整、有无引流静脉受压 ,肿瘤组织的恶性程度 ,血管内皮生长因子 (vascu1arendothelialgrowthfactor,VEGF)免疫组织化学染色与瘤周水肿的相关性。 结果脑膜瘤瘤周水肿与肿瘤大小、有无引流静脉受压、病理类型、肿瘤组织的恶性程度无相关性 ,与肿瘤包膜是否完整 (P <0 .0 1)、肿瘤组织中VEGF的表达水平高度相关 (P <0 .0 0 1)。 结论脑膜瘤对正常脑屏障的破坏是造成瘤周水肿的解剖基础 ,肿瘤细胞分泌的致水肿因子 (VEGF)是造成脑水肿的直接原因。
Objective To study the factors associated with meningioma peritumoral edema. Methods Peritumoral edema of l8 patients was assessed on a semi-quantitative form from preoperative radiography.All the patients' clinical information(tumor size,tumor envelope damage,brain surface vein compression,pathological type),malignancy of tumor tissue,vascular endothelial growth factor(VEGF), immuno-histo-chemisty stain were studied to find out the correlation with peritumoral edema. Results There was no correlation between tumor size,pathological type and brain vein compression with peritumoral edema。Tumor envelope damage and VEGF immunoreactivity were strongly associated with peritumoral edema. Conclusion These data suggest that meningioma peritumoral edema may be a result of tumor cell producing VEGF in combination with tumor envelope damage,which lead to the damage of normal blood brain barrier and the enterance of edema-causing chemical factor.
出处
《上海第二医科大学学报》
CSCD
2000年第4期331-333,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
脑膜瘤
瘤周水肿
血管内皮生长因子
meningioma peritumoral edema vascular endothelial growth factor
