摘要
目的:探讨蛋白质芯片技术在妊娠期高血压疾病早期诊断中的应用效果。方法:选取2008年4月～2008年10月经我院妇产科确诊的妊娠期高血压疾病患者16例(实验组)和同期正常孕妇16例(对照组),采用蛋白质芯片(SELDI)技术,比较两组血清差异蛋白质相对含量和血清蛋白质谱图差异。结果:在质荷比2000～20000D范围内,妊娠期高血压患者中(3189.885、3268.658、6516.054、13817.78)质荷比相对含量(11.36±3.93、16.42±4.65、6.15±0.41、9.52±0.82)明显高于正常分娩孕妇(1.91±0.48、4.68±0.81、2.71±1.23、3.76±1.4),两组经统计学处理差异有显著性(P<0.05)。结论:(3189.885、3268.658、6516.054、13817.78)可能成为妊娠高血压疾病早期筛查的血清标志物。
Objectives： To study the efficacy of protein chip technology in early diagnosis of pregnancy hypertensive disorder. Method： Protein chip technology （ SELDI ） was used to compare the relative content of differently expressed proteins and se- rum protein spectrum of 16 HDCP women （ experimental group） in our hospital from April 2008 to October 2008 and 16 normal pregnant women （control group）, with. Results： with mass - to - charge ratio in the range of 2000 -20000D, experimental group （3189. 885, 3268. 658, 6516. 054, 13817.78 ） showed significantly higher relative content of mass- to- charge ratio （11.36 ±3.93,16.42±4.65,6. 15 ±0.41,9.52±0.82） than that of control group （1.91 ±0.48,4.68±0.81,2.71±1.23, 3.76 ± 1.4）. There was significant difference （ P 〈 0. 05 ）. Conclusions： （ 3189. 885, 3268. 658, 6516. 054, 13817. 78 ） may become serum markers in early screening for pregnancy hypertensive disorder.
出处
《中国性科学》
2012年第7期25-26,34,共3页
Chinese Journal of Human Sexuality
