摘要
全基因组序列拼接是生物信息学研究领域的核心问题。针对新一代测序数据读取片段reads长度短、数据海量、精确度低等特点带来的严峻挑战,能够满足实际应用的序列拼接软件的研发,已成为生物信息学领域最为迫切的研究课题。深入探讨全基因组序列拼接的发展动态、所采用的主要策略等方面,总结序列拼接相关理论,并为未来新算法的研发提出具体的改进建议。
Whole genome assembly is the core issue ofbioinformatics. On conditions that next generation sequencing brings bioinformatics an unprecedented challenge due to its data of mass, short length and relatively low precision, development of sequence assembly software that could meet practical application has.become the most important research topic. This paper analyses the development progress and main strategies of whole genome assembly deeply, sums up the relevant theory and provide specific suggestions for future algorithms.
出处
《智能计算机与应用》
2012年第4期4-7,13,共5页
Intelligent Computer and Applications
