摘要
目的:探讨载脂蛋白A5(APOA5)c553G/T基因多态性与急性冠状动脉综合征(ACS)的相关性。方法:以254例ACS患者(ACS组)和229名健康对照者(对照组)为研究对象,用聚合酶链反应限制性片段长度多态性分析G/T位点多态性的分布,并用酶法检测血脂水平。结果:APOA5c553T等位基因在ACS组中的分布频率明显高于对照组(P<0.05),对ACS具有独立的影响(OR=2.344,P<0.01)。2组APOA5c553TT纯合子及GT杂合子个体比GG纯合子个体具有高TG、TC、LDL水平和低HDL水平。结论:APOA5c553G/T基因多态性与血浆TG、TC、HDL和LDL具有相关性。APOA5c553T等位基因可能为ACS的危险因素。
Objective：To investigate the relationship between the polymorphism of apolipoprotein A5（APOA5） gene c553G/T and acute coronary syndrome（ACS）.Method：Two hundred and fifty-four patients with ACS（ACS group） and 229 healthy controls（control group） were collected to determine the genotypes by using polymerase chain reaction restriction fragment length polymorphis,and the levels of blood lipid were detected by enzymic method.Result：The frequency of APOA5 c553T genotype in ACS group was significantly higher than that in control group（P〈0.05）,and the APOA5 c553T allele was an independent risk factor of ACS（OR=2.344,P〈0.01）.TT homozygotes and GT heterozygotes had higher TG（P〈0.05）,TC,LDL levels and lower HDL when compared with GG homozygotes in both groups.Conclusion：APOA5 c553G/T polymorphism is related with plasma TG,TC,HDL and LDL levels.APOA5 c553T genotype may be an independent risk factor of ACS.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第8期590-592,共3页
Journal of Clinical Cardiology
