摘要
通过研究离子液体四氟硼酸1-丁基-3-甲基咪唑([Bmim]BF4)-Na2CO3双水相体系对头孢呋辛酯的萃取性能,建立了萃取环境水样中头孢呋辛酯的双水相法。考察了双水相体系组成及相关条件对萃取率的影响,并对其萃取作用力及萃取机制进行了探索。结果表明,Na2CO3用量为0.8～2.0 g,[Bmim]BF4用量为1～2 mL时,随着二者用量的增加,萃取率有所增加。与[Bmim]Cl/Na2CO3双水相体系相比,[Bmim]BF4/Na2CO3双水相体系更适于萃取头孢呋辛酯。热力学参数ΔG°T<0,ΔH°T>0,ΔS°T>0,说明萃取过程的主要推动力为疏水性相互作用。在最佳萃取条件下,用此方法萃取环境水样中的头孢呋辛酯,二次萃取率大于93%,重现性好。整个萃取过程快速、高效且无乳化现象。
As an effective extraction method,ionic liquid aqueous two-phase systems（ILATPS） based on 1-butyl-3-methylimidazolium tetrafluoraborate（BF4） and Na2CO3 has been used to extract cefuroxime axetil.Effects of the ionic liquids concentration,Na2CO3 dosage and sort of ionic liquids on the extraction have been investigated.The thermodynamic parameters（ΔG°T,ΔH°T and ΔS°T） were determined.This method was applied to the determination of cefuroxime axetil in real water samples.The results showed that extraction efficiency of cefuroxime axetil was found to increase with increasing Na2CO3 and BF4 at the range of Na2CO3 0.8-2.0 g and BF4 1-2 mL.Compared with Cl/Na2CO3 ILATPS,BF4/Na2CO3 ILATPS has more advantages.The thermodynamic parameters ΔG°T〈0,ΔH°T〉0,ΔS°T〉0 illustrate that hydrophobic interactions were the main driving force in the BF4/Na2CO3 ILATPS of cefuroxime axetil extraction,the extraction process did not occur emulsification.Under the optimum conditions,more than 93% of the cefuroxime axetil in real water could be extracted into the ionic liquid-rich phase in a two-step extraction.
出处
《分析化学》
SCIE
CAS
CSCD
北大核心
2012年第8期1252-1256,共5页
Chinese Journal of Analytical Chemistry
基金
"重大新药创制"科技重大专项(No.2009ZX09301-006)
"重大新药创制"科技重大专项(No.2009ZX09103-653)资助
关键词
离子液体双水相
萃取
头孢呋辛酯
Ionic liquid aqueous two-phase systems； Extraction； Cefuroxime axetil
