摘要
目的探讨血浆EBV-DNA水平与VCA-IgA联合检测对鼻咽癌诊断的临床意义。方法收集鼻咽癌患者88例,健康体检者45例作为对照组。采用荧光定量PCR方法检测EBV-DNA水平,采用酶联免疫吸附法检测VCA-IgA抗体滴度。结果鼻咽癌患者中,EBV-DNA阳性率81.82%,VCA-IgA阳性率89.77%,健康体检者中,EBV-DNA阳性率6.67%,VCA-IgA阳性率31.11%,两组阳性率有显著差异(P<0.01);早期(I、Ⅱ期)鼻咽癌患者EBV-DNA水平及VCA-IgA滴度与晚期(III、IV期)鼻咽癌患者EBV-DNA水平及VCA-IgA滴度有显著差异(P<0.05)。结论血浆EBV-DNA与VCA-IgA联合检测对鼻咽癌的诊断有极高价值,可作为监测病情的一种有效手段。
Objective TO investigate the clinical significance of combined of plasma EBV-DNA and VCA-IgA in the diagnosis of nasopharyngeal carcinoma. Methods Included in this study were 88 cases with nasophryngeal carcinoma, 45 cases healthy persons as control. Using the method of polymerase chain reaction to test plasma EBV-DNA, linked immunosorbent assay to test VCA-IgA. Results The positive rate of plasma EBV-DNA was 81.82%,the positive rate of VCA-IgA was 89.77% in the nasopharyngeal carcinoma group, the positive rate of plasma EBV-DNA was 6.67%,the positive rate of VCA-IgA was 31.11% in the control group, there were all more significant differences between them （P〈0.01）;the level of plasma EBV-DNA and VCA-IgA was lower at early stage （stage I and II） than at late stage （stage III and IV） in the nasopharyngeal carcinoma group （P〈0.05）.Conclusion Plasma EBV-DNA and VCA-IgA may be a valuble technique for diagnosing with nasopharyngeal carcinoma and predicting the prognosis.
出处
《中国实用医药》
2012年第19期46-47,共2页
China Practical Medicine
