摘要
【目的】探讨原发性干燥综合征伴周围神经损害的临床特点和病理改变。【方法】回顾分析原发性干燥综合征伴周围神经损害病例的临床及病理资料。【结果】4例患者周围神经损害早于外分泌腺。3例有感觉性共济失调性神经病,其中1例伴颅神经损害,1例伴自主神经损害。1例腓肠神经活检可见节断性脱髓鞘改变,伴炎细胞浸润。【结论】原发性干燥综合征周围神经损害可能早于外分泌腺。周围神经损害临床表现多样,病理改变复杂。
[ Objective ] To explore the clinical and pathological features of peripheral neuropathy in primary sjogren＇s syndrome （PSS）. [Methodsl We retrospectively studied 4 patients with PSS associated with peripheral neuropathy. [Results] The clinical manifestations of peripheral neuropathy preceded the development of sicca syndrome in 4 cases of primary sjogren＇s syndrome. 3 cases had sensory ataxic neuropathy , among them,1 case overlapped autonomic neuropathy and 1 case overlapped cranial neuropathy.1 case had radiculoneuropathy .Sural nerve biopsy was performed in a patient and peripheral neuropathy was demyelinated with lymphocytic infiltration. [Conclusions] The clinical manifestations of peripheral neuropathy may precede the development of sicca syndrome in primary sjogren＇s syndrome.The peripheral neuropathy has a broad spectrum and complicated pathological features.
出处
《武警医学院学报》
CAS
2012年第7期536-538,共3页
Acta Academiae Medicinae CPAPF
