摘要
目的:探讨子宫内膜癌(EC)组织中P27及P73蛋白的表达及临床意义。方法:采用SP法检测46例EC患者(EC组)和20例正常子宫内膜组织(对照组)中P27、P73蛋白的表达,并分析二者相关性。结果:EC组织中P27蛋白表达明显低于正常子宫内膜(P<0.01),P73蛋白表达明显高于正常子宫内膜(P<0.01)。不同临床分期子宫内膜癌患者组织中P27、P73蛋白的表达差异无统计学意义(P均>0.05)。不同组织学分级者P27、P73蛋白表达差异有统计学意义(P<0.05),中、低分化患者P27蛋白表达明显低于高分化者(P均<0.05),中、低分化者表达差异无统计学意义(P均>0.05);高、中分化者P73蛋白表达差异无统计学意义(P>0.05),高、中分化者P73蛋白表达低于低分化者(P均<0.05);P27与P73蛋白表达阳性者在EC组织中的表达无明显相关(P>0.05)。结论:P27、P73蛋白表达可能参与了子宫内膜癌的发生、发展。
Objective： To investigate the expression of P27 and P73 in endometrial carcinoma（EC）.Methods：A total of 46 EC patients and 20 normal persons were included.Expression of P27 and P73 proteins were detected by SP method and the relationship between proteins and EC was analyzed.Reuslts： P27 expression was significantly lower and P27 was significantly higher in EC patients（P〈0.01）.There was no significant difference in P27 and P73 expression among EC patients at different stage（P〉0.05）,while the difference was significant among patients with difference histological stage（P〈0.05）.P27 protein was significantly higher in patients with high differentiation,but there was no significant difference between patients with middle and low differentiation（P〉0.05）.P73 protein was significantly higher in patients with lower differentiation（P〉0.05）,but there was no significant difference between patients with middle and high differentiation（P〉0.05）.There was no significant correlation between positive expression of P27 and P73 and EC.Conclusions： P27 and P73 protein may be involved in the occurence and progression of EC.
出处
《海南医学院学报》
CAS
2012年第8期1037-1039,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210259)~~
