摘要
目的:观察鸦胆子油乳联合NP方案化疗与单纯NP方案化疗对晚期肺小细胞癌患者的疗效、生活质量等因素的影响。方法:将154例患有晚期非小细胞肺癌患者随机分为两组:治疗组,在NP方案化疗基础上使用鸦胆子油乳治疗;对照组,单纯接受NP方案化疗。对154例患者追踪3个月,观察并比较患者的疗效、体质量、生活质量、毒副反应等方面的差异。结果:在NP方案化疗基础上使用鸦胆子油乳治疗在患者疗效评价方面与单纯NP方案化疗相比不具有统计学差异(P>0.05);在提高患者体质量、改善患者临床症状和生活质量等方面均优于单纯NP方案化疗(P<0.05);在化疗所引发的白细胞、血红蛋白和血小板降低等部分毒副反应发生率方面低于单纯NP方案化疗组(P<0.05)。结论:鸦胆子油乳联合NP方案化疗治疗晚期非小细胞肺癌不仅可以起到化疗增效的作用,而且能够明显提高患者生活质量,有效的改善临床症候,降低化疗引发的毒副反应,这一联合治疗方案可以在临床治疗中广泛推广。
Objective： To observe the differences between pure chemotherapy and Fructus Brucea Oil emulsion （FBE） combination with chemotherapy of NP regimen treatment for therapeutic effect and the quality of life with advanced non-small cell lung cancer （NSCLC） patients. Methods： 154 cases advanced NSCLC patients were randomly divided into chemotherapy group and FBE combination with chemotherapy group. Chemotherapy group was treated with NP scheme （vinorelbine, NVB and cis-platinum, DDP）. At the same time the other group was treated with FEB and NP regimen. All patients were observed for three months and the differences were ana- lyzed in the therapeutic effect score, body quality score, quality of life score and toxic effect. Results： FBE combination with NP regimen was superior to NP regimen in the improvement of body quality score, quality of life score and the decrease of toxic effect （P〈0.05）. But the combined regimen was not better than NP regimen in the improvement of therapeutic effect score （P〉0.05）. Conclusion： FBE combi- nation with NP regimen could improve the life quality and body quality of the patients and decrease the incidence of toxic effect induced by chemotherapy.
出处
《现代生物医学进展》
CAS
2012年第21期4079-4082,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(30770823)
关键词
鸦胆子油乳
NP
非小细胞肺癌
临床疗效
Fructus Brucea Oil emulsion
NP
Advanced Non-small Cell Lung Cancer
Therapeutic Effect
