摘要
目的探讨高通量血液透析对维持性血液透析(MHD)患者血浆白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)水平的影响。方法将32例MHD患者随机分为两组,采用聚砜膜分别进行高通量血液透析(HFHD)与低通量血液透析(LFHD),测定其透析前后的血浆IL-10、IL-6、hs-CRP的水平;同时选择14例健康志愿者作为对照组。结果 HFHD组、LFHD组透析前IL-10、IL-6和hs-CRP的血浆水平均显著高于对照组(P<0.05);HF-HD组透析后IL-10、IL-6、hs-CRP的血浆水平与透析前相比差异均无统计学意义(P>0.05),LFHD组透析后IL-10、IL-6和hs-CRP的血浆水平均显著高于透析前(P<0.05);HFHD组与LFHD组透析后IL-10、IL-6和hs-CRP的血浆水平比较差异均无统计学意义(P>0.05)。结论 MHD患者存在血浆IL-10、IL-6和hs-CRP水平的异常增高,HFHD未升高血浆炎性细胞因子的水平,是目前较好的血液净化技术。
Objective To investigate the effects of high-flux hemodialysis on plasma interleukin-10 （IL-IO）, interleukin-6 （IL-6） and high sensitive C-reactive protein（hs-CRP） in maintenance dialysis（MHD） patients. Methods Thirty-two MHD patients were randomly divided into two groups, and treated by using the high-flux hemodialysis （HFHD） and low-flux hemodialy- sis（LFHD） with dialyzer of polysulfone membranes. The plasma levels IL-10,IL-6 and hs-CRP before and after the dialysis was measured in the two groups and fourteen healthy controls. Results The plasma levels of IL-10, IL-6 and hs-CRP before and after the dialysis in both dialysis groups were significant elevated as compared to control groups （ P 〈 0.05 ）. The plasma levels of IL- 10 ,IL-6 and hs-CRP after the dialysis were no significant differences in groups with HFHD as compared to its levels before（ P 〉 0.05 ）, those parameters after the dialysis increase significantly in patients with LFHD as compared to its levels before dialysis （P 〈 0.05 ）. The plasma levels of IL-10, IL-6 and hs-CRP after the dialysis were no significant differences between the two dialysis groups （ P 〉 0.05 ）. Conclusion Inflammatory cytokines were significantly higher in MHD patients. HFHD cannot lead to elevate inflammatory cytokines and, consequently, is considered to be the better renal replacement therapy.
出处
《中华全科医学》
2012年第9期1370-1371,1419,共3页
Chinese Journal of General Practice
