摘要
目的探讨高通量血液透析联合复方α酮酸片对血液透析患者营养不良及微炎症状态的影响。方法将102例行维持性血液透析患者随机分为3组。A组患者采用普通通量血液透析模式,B组患者采用高通量血液透析模式,C组患者在采用高通量血液透析的基础上联合复方α酮酸片治疗。治疗观察6个月。比较三组透析患者的血肌酐、尿素氮、血清总蛋白、血清白蛋白等生化指标,人体测量学指标,超敏C反应蛋白(hsCRP)、白介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)微炎症指标。结果干预6个月后,C组患者BM I、M AC、TSF、TP、ALB升高(P<0.05),且高于A组(P<0.05);hs-CRP、IL-6水平降低(P<0.05),且低于其他两组;TNF-α明显降低(P<0.05),与其他两组比较差异无统计学意义(P>0.05)。结论高通量血液透析联合复方α酮酸可明显改善维持性血液透析患者的营养状况,对微炎症状态控制良好,优于单用高通量血液透析或普通血液透析。
Objective To investigate the effect of high-flux hemodialysis with compound α-keto acid tablets on malnutrition and micro-inflammatory state. Methods 102 MHD （maintenance hemodialysis）patients were randomly divided into 3 groups, patients in group A, group B and group C received ordinary flux hemodialysis mode, high-flux hemodialysis mode and high-flux hemodialysis with compound oL-keto acid tablets therapy respectively. The treatment lasted for 6 months. The serum creatinine, blood urea nitrogen, serum total protein, serum ALB and other biochemical indicators, anthropometric indicators, changes of hs-CRP, IL-6 and TNF-α in the three groups were compared. Results The BMI, MAC, TSF, TP and ALB of group C increased significantly （P 〈 0. 05 ） , and there were significant differences between group C and group A （ P 〈 0. 05 ） ; hs-CRP, IL-6 （ compared with another groups, P 〈 0. 05 ） and TNF-α （ compared with another groups, P 〉 0. 05 ） significantly decreased in group C （ P 〈 0. 05 ）. Conclusion High flux he- modialysis with compound α-keto acid can significantly improve the malnutrition, micro-inflammatory state of MHD patients, the effect is better than single high-flux or low-flux hemodialysis.
出处
《实用药物与临床》
CAS
2015年第4期409-412,共4页
Practical Pharmacy and Clinical Remedies
基金
浙江省医药卫生科技基金项目(2012KYB226)
关键词
高通量血液透析
复方α酮酸片
微炎症
营养不良
High-flux hemodialysis
Compound α-keto acid
Micro-inflammatory
Malnutrition
