摘要
喹烯酮是国家的一类新型兽药。由于其在生物体内的利用率低,喹烯酮代谢物1-(3-甲基喹喔啉-2-基)-3-苯基2-丙烯-1-醇难于从生物的排泄物中分离与鉴定。文章以喹烯酮为原料,经三氯化磷以及四氢锂铝还原后,首次合成喹烯酮的代谢物1-(3-甲基喹喔啉-2-基)-3-苯基2-丙烯-1-醇,两步收率达75%。各步化合物经高效液相色谱、质谱、氢核磁谱等分析手段,验证结构符合。
Quincetone is a new class of veterinary drugs. For low bioavailablity of quinocetone in animals, it is difficult to separate and identify the metabolite of quinocetone from excreta. A method for synthesis of the metabolites of quincetone was reported. We got the target compound of 1-（3-methylquinoxalin-2-yl）-3-phenylprop-2-en-1-ol by reducing with phosphorus trichloride and lithium aluminum hydride for the first time. The two steps were prepared with overall yield of 75 %. The title compounds ware confirmed with HPLC, MS, 1H-NMR et al.
出处
《广东化工》
CAS
2012年第7期29-29,44,共2页
Guangdong Chemical Industry
