摘要
为了研究喹烯酮在鱼体内的药物代谢动力学及组织分布情况,在(15±1)℃的水温条件下,按50mg/kg单剂量口服给药后,采用高效液相色谱法测定喹烯酮在鲤、斑点叉尾鮰血浆与组织中的药物浓度。结果,喹烯酮在鲤和斑点叉尾鮰体内的药代动力学模型均符合两室开放模型。喹烯酮在鲤血液中2h时达到最高血药浓度(Cmax)为0.452μg/mL,在肝、肾、肌肉组织中达峰时间分别为8、16和16h,主要药代动力学参数t1/2(ka)、t1/2β、AUC分别为1.263h、35.866h、24.585(μg/mL)·h;喹烯酮在斑点叉尾鮰血液中8h达到最高血药浓度(Cmax)为0.029μg/mL,在肝、肾、肌肉组织中达峰时间分别为16、48和72h,主要药代动力学参数t1/2(ka)、t1/2β、AUC分别为4.669h、31.164h、1.388(μg/mL)·h。结果表明,喹烯酮在鲤与斑点叉尾鮰体内吸收较快,分布较广,主要经肝、肾代谢。
In order to study the pharmacokinetics and tissue distribution of quinocetone in fishes,after single oral administration（50mg/kg according to body weight）,quinocetone was investigated by using high performance liquid chromatography to determine its concentration in plasma and tissues of carp and channel catfish at 15℃±1℃ water temperature.In result,pharmacokinetic model of quinocetone in the plasma of carp and channel catfish could be described as a two-compartmental open model.The concentration of quinocetone in the plasma of carp amounted to the largest（0.452μg/mL） at 2h,and in the liver,kidney and muscle at 8h,16h and 16h respectively.The main pharmacokinetic parameters t1/2（ka）,t1/2β and AUC were 1.263h,35.866h and 24.585（μg/mL）·h respectively.The concentration of quinocetone in the plasma of channel catfish amounted to the largest（0.029μg/mL） at 8h and in the liver,kidney and muscle at 16h,48h and 72h respectively.The main pharmacokinetic parameters t1/2（ka）,t1/2β and AUC were 4.669h,31.164h and 1.388（μg/mL）·h respectively.The results showed that quinocetone was absorbed quickly and distributed diffusely in carp and channel catfish and was mainly metabolized by the liver and kidney.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2010年第5期537-542,共6页
Chinese Veterinary Science
关键词
喹烯酮
鲤
斑点叉尾鮰
高效液相色谱
药代动力学
quinocetone
carp
channel catfish
high performance liquid chromatography
pharmacokinetics
