摘要
研究了粒细胞集落生长因子（G－CSF）促进受辐射小鼠造血功能恢复的作用，并对机理进行了初步探讨。结果表明：G－CSF不仅可以促进受辐射小鼠外周血细胞的恢复；促进脾脏内源性脾结节的形成，而且可以增加骨髓细胞含量和促进骨髓细胞巨噬系造血祖细胞（CFU－GM）的形成，提高受辐射小鼠的生存率，其促进辐射后机体造血功能恢复的机理是通过刺激照射后残余造血于细胞的增殖、分化，该过程需要一段较长的时间，而不是抑制照射后即刻细胞的程序性死亡。
This article is to study the rehabilitate effects of G-CSF on hemotological function and its mechanism. The results indicate that G-CSF can not only accelerate the recovery of peripheral blood, promote the recovery of endogenous CFU-S,but also increase the number of bone marrow cell and stimulate its CFU-GM. It can raise the 30th days survival rate of irradiated mice. The mechanism is due to accelerative action on the recovery of hematological function in exposed mice. This procedure needs a long time. It is not due to the inhibitory upon programmed cell death of cells.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
2000年第2期142-147,共6页
Journal of Radiation Research and Radiation Processing
