摘要
为探讨内皮素 (ET)在不同类型冠心病患者血浆中的变化及其意义 ,本文采用Meta分析对所收集的国内相关研究文献进行定量综合分析。结果提示 ,急性心肌梗死 (AMI)组、不稳定型心绞痛 (UA)组和稳定型心绞痛 (SA)组患者的血浆ET含量分别比正常对照组高出 2 .34～ 0 .92、3.6 6～ 0 .76和 5.50～ 0 .84倍标准差。而UA组和AMI组又比SA组高出 1.55～ 0 .4 5和 2 .98～0 .2 8倍标准差 ,AMI组又比UA组高 1.4 8～ 0 .0 2倍标准差。本文得出结论是 :ET的血浆含量随着冠心病的病变程度加重而升高 ,测定血浆ET含量可作为判断冠心病严重程度的新的指标。
To investigate the significance of plasma endotheline (ET) levels in patients with different coronary heart diseases (CHD), synthetic quantitative analysis was used to study internal literatures on plasma ET change by means of Meta-analysis. The results showed that the levels of plasma ET in the patients with acute myocardial infarction (AMI), or unstable angina(UA), or stable angina(SA), were 2.34～0.92,3.66～0.76 or 5.50～0.84 times of standard deviation higher than those in the healthy control group, respectively. Moreover, plasma ET levels in patients with UA or AMI were 1.55～0.45 times or 2.98～0.28 times of standard deviation higher than those in patients with SA,respectively.And the levels of plasma ET in patients with AMI were 1.48～0.02 times of standard deviation higher than those in the patints with UA.Conclusion: The higher the plasma ET levels the patients had, the more serious CHD were. Plasma ET levels may be a new parameter as to monitor the sever degree of CHD.
出处
《标记免疫分析与临床》
CAS
2000年第1期4-8,共5页
Labeled Immunoassays and Clinical Medicine
关键词
内皮素
血浆
冠心病
META分析
Endotheline/plasma Coronary heart disease Meta-analysis
