摘要
本文采用放射免疫分析法测定了20例正常人及40例Ⅱ型糖尿病患者的血浆内皮素水平。结果显示,糖尿病患者的血浆内皮素水平显著高于正常人。伴有微血管病变的患者较未伴有微血管病变者,血浆内皮素水平也明显升高。患者血浆内皮素水平与血小板聚集率和尿白蛋白排泄率成正相关。表明:血小板功能异常可能是造成血管内皮细胞损伤,进而引起血浆内皮素水平升高的原因之一,并提示血浆内皮素的升高对于糖尿病微血管病变可能有重要作用。
Plasma endothelin-1(ET-1) levels were measured with radio-immunoassay in 20 normal subjects and 40 patients with type 2 diabetes mellitus. Plasma ET-1 concentrations were found to be greatly elevated in the diabetic patients compared with the normal subjects. We also found the plasma ET-1 levels were higher in diabetic patients with microangiopathy than those of patients without microangiopathy. There was significant positive correlation between ET-1 level and platelet aggregation rate and uAER. In diabetic patients,elevated ET-1 levels may play a pathophysiological role in the development of diabetic microangiopathy.
出处
《交通医学》
1999年第3期304-305,共2页
Medical Journal of Communications
