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法舒地尔治疗缺血性脑梗死疗效分析

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摘要 目的观察法舒地尔治疗缺血性脑梗死的临床疗效。方法将100例缺血性脑梗死患者随机分为治疗组50例和对照组50例。治疗组予法舒地尔注射液30mg+氯化钠注射液100ml静脉滴注,每天2次;对照组予曲克芦丁注射液0.4g+氯化钠注射液250ml静脉滴注,每天1次。疗程均为15d。治疗后`比较2组疗效。结果治疗组总有效率为90%高于对照组的72%,差异有统计学意义(P<0.05)。结论法舒地尔对缺血性脑血管病有显著的神经保护和治疗作用,可减少致残率、提高患者生活质量。
作者 王治琴
出处 《临床合理用药杂志》 2012年第22期105-105,共1页 Chinese Journal of Clinical Rational Drug Use
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  • 1Kajimoto H,Hashimoto K,Bonnet SN,et al.Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species:a newly recognized mechanism for sustaining ductal constriction[J].Circulation,2007,115(13):1777-1788. 被引量:1
  • 2Rikftake Y,Kim YY,Huang Z,et al.lnhibition of Rho kinase(ROCK) leads to increased cerebral blood flow and stroke protection[J].St roke,2005,36:2251-2257. 被引量:1
  • 3Takemoto M,Sun J,Hiroki J,et al.Rho2kinase mediates hypoxiainduced down-regulation of endothelial nitric oxide synthase[J].Circulation,2002,106:57. 被引量:1
  • 4Wolfrum S,Oendorfer A,Rikitake Y,et al.Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection[J].Arterioscler Thromb Vasc Biol,2004,24:1842-1847. 被引量:1
  • 5Matsumoto Y,Uwatoku T,Oi K,et al.Long2term inhibition of Rhokinase suppresses neointimal formation after stent implantation in porcine coronary arteries:Involvement of multiple rnechanisms[J].Arterioscler Thromb Vasc Biol,2004,24:181. 被引量:1
  • 6Abe K,ghimokawa H,Morikawa K,et al.Long2term treat ment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats[J].Circ Res,2004,94(3),3B5-393. 被引量:1
  • 7Wettschureck N,Offermanns S.Rho/Rho-kinase mediated signaling in physiology and pathophysiology[J].J Mol Med,2002,80:629-638. 被引量:1
  • 8Melanie Yeoh,James A.Brock.Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro[J].British Journal of PharmacoIogy,2205,146:854-861. 被引量:1
  • 9Shimokawa H,Hiramori K,linuma H,et al.Anti-anginal effect of Fasudil,a Rho-kinsse inhibitor,in patients with stable effort angina:A multicenter study[J].J Cardiovasc Pharmacol,2002,40(5):751-761. 被引量:1
  • 10Fukumoto Y,Matoba T,Ito A,et al.Acute vasodilator effect of a Rho-kinase inhibitor,fasudil,in patients with severe pulmonary hypertension[J].Heart,2005,91:391-392. 被引量:1

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