摘要
静脉注射氧化苦参碱 (5mg/kg、10mg/kg)对麻醉猫血流动力学多项指标有显著影响 ,能增加心输出量、左室作功指数、心脏指数、心搏指数 ,升高左室内压、升高左室内压最大上升速率 ,延长心肌收缩的缩短速度 ,缩短间隔时间 ,降低心率、左室输张末期压 (P <0 .0 5或P <0 .0 1) ,但对外周血管阻力无明显影响 (P >0 .0 5 ) ,表明氧化苦参碱能增加心肌收缩性能 ,增加心输出量 ,降低心率 ,改善心脏泵血功能 ,产生有益的血流动力学效应 .
In anesthetized openchest cats,oxymatrine (Om)(5,10 mg/kg),i.v had remarkable effects on the heart functions and hemodynamics. CO, LVP, dp/dt max ,V CECPIP ,LVWI,CI,SI increased and HR,LVEDP,tdp/dt max decreased (P<0.05 or P<0.01).There was no significant change in TPVR.The data indicated that Om enhanced cardiac contractility,increased stroke volume,decreased HR,and improved cardiac efficiency and hemodynamics effects.
出处
《沈阳药科大学学报》
CAS
CSCD
2000年第2期140-142,共3页
Journal of Shenyang Pharmaceutical University
