摘要
目的 探讨胃癌ｐ３５ 、ＰＫＣ 及ＣＤ４４ Ｖ６ 联合表达与淋巴结转移的关系。方法 采用免疫组化ＳＡＢＣ 法检测８０ 例胃癌组织中ｐ５３ 、ＰＫＣ 及ＣＤ４４ Ｖ６ 的表达。结果 胃癌组织中ｐ５３ 、ＰＫＣ 及ＣＤ４４Ｖ６ 表达阳性率分别为５５ ．０ ％ 、５１ ．３ ％ 和５７ ．５ ％ 。ｐ５３ 、ＰＫＣ 及ＣＤ４４ Ｖ６ 阳性表达者淋巴结转移率分别为７９ ．５ ％ 、８５ ．４ ％ 和８０ ．０ ％ ，均高于阴性者（５５ ．６ ％ 、５１ ．３ ％ 和５２ ．９ ％ ） ，具有显著性差异（ 分别 Ｐ＜ ０ ．０５ ，Ｐ＜ ０ ．０１ ，Ｐ＜ ０ ．０５） 。同时有２ 个以上指标表达者淋巴结转移率为８４ ．８ ％ ，明显高于表达１ 个指标（５３ ．５ ％ ） 和３ 个指标均不表达者（４２ ．１ ％ ） ，均有显著性差异（ Ｐ＜ ０ ．０５ ，Ｐ＜ ０ ．０１） 。结论 ｐ５３ 基因突变、细胞内信号传导失常以及ＣＤ４４ 异常表达与胃癌淋巴结转移有关，三者在淋巴结转移中具有协同作用。
Objective To study the relationship between lymph node metastasis and p53,PKC and CD44V6 in human gastric cancer.Methods p53,PKC and CD44V6 expression in human gastric cancer tissues of 80 cases were observed by immunohistochemical SABC method.Results The positive rates of p53,PKC and CD44V6 expression were 55.0%,51.3% and 57.5%,respectively,the metastatic rates in p53,PKC and CD44V6 positive tumour(79.5%,85.4%,80.4%) were higher than in those with negative p53,PKC and CD44V6 expression(55.6%,51.3%,52.9%;χ 2=5.30,10.81,6.88; P <0.05, P <0.01, P <0.05).Meanwhile,the metastatic rates in those with co expressions of two or three targets were higher than in that with only one or none of expression( 84.8% ,53.5%,42.1%;χ 2=6.33,12.23; P <0.05, P <0.01).Conclusion p53,PKC and CD44V6 were related with lymph node metastasis in human gastric cancer.They may play a combined role in gastric cancer metastasis.
出处
《实用癌症杂志》
2000年第1期32-33,共2页
The Practical Journal of Cancer
