摘要
环氧合酶-2（COX-2）在白血病发生发展过程中具有重要作用，而COX-2抑制剂具有一定的抗白血病作用。大量研究已证实，COX-2抑制剂可通过抑制白血病细胞增殖、促进细胞凋亡、影响细胞周期、抑制白血病细胞转移、逆转白血病细胞耐药等来发挥其抗白血病作用。因此，有关COX-2抑制剂抗白血病作用机制的研究将为白血病的预防和治疗寻找新的靶点。
Cyclooxygenase-2 （COX-2） plays an important role in the development of leukemia. COX-2 inhibitor plays a certain anti-leukemia role in the process. Many studies show that COX-2 inhibitor plays anti- leukemia role by inhibiting the proliferation of leukemia cell, promoting apoptosis, affecting cell cycle, inhibi- ting cell metastasis and reversing cell drug resistance and so on. Therefore, the researches about the anti-leukemia mechanisms of COX-2 inhibitor will provide a new target in clinical prevention and treatment of leukemia.
出处
《国际肿瘤学杂志》
CAS
2012年第6期462-464,共3页
Journal of International Oncology
