摘要
目的:观察瑞格列奈联合二甲双胍控制糖尿病合并肺结核血糖的疗效。方法:将65例糖尿病合并肺结核住院患者随机分成2组:治疗组34例给予瑞格列奈片1～2mg,tid+二甲双胍片0.25～0.5g,tid;对照组31例给予二甲双胍片0.25～0.5g,tid+格列齐特片80mg,bid。2组均连续治疗2个月。观察2组用药后空腹血糖、餐后血糖、糖化血红蛋白值的变化。结果:2组用药后空腹血糖、餐后血糖、糖化血红蛋白均显著下降(P<0.05),但与对照组比较,治疗组下降更为显著(P<0.01)。另外,瑞格列奈、格列齐特均能促进早期胰岛素分泌。结论:瑞格列奈片联合二甲双胍片治疗糖尿病合并肺结核具有协同作用,可较好地控制血糖,同时采取合理抗结核治疗,能提高肺结核的治愈率,副作用少,依从性好。
OBJECTIVE:To observe the therapeutic efficacy of Repaglinide tablet and Metformin tablet in the treatment of diabetic patients with tuberculosis.METHODS:65 diabetes inpatients with pulmonary tuberculosis were randomly divided into 2 groups:34 patients in treatment group were given Repaglinide tablet 1～2 mg and Metformin tablet 0.25～0.5 g 3 times a day;31 patients in control group were given Metformin tablet 0.25～0.5 g and Repaglinide tablet 80 mg,bid.The treatment course of 2 groups lasted for 2 months.The change of blood glucose,postprandial blood glucose and glycated hemoglobin were observed.RESULTS:The fasting blood glucose,postprandial blood glucose and glycated hemoglobin of 2 groups decreased significantly after treatment(P<0.05),and the decrease of treatment group decreased significantly compared with control group(P<0.01).Repaglinide and gliclazide could promote early insulin secretion.CONCLUSION:Repaglinide tablet and Metformin tablet have a synergistic effect on diabetes combined with pulmonary tuberculosis and obtain better blood glucose control.It can improve the cure rate of tuberculosis with less side effects and good compliance.
出处
《中国药房》
CAS
CSCD
2012年第28期2634-2636,共3页
China Pharmacy
关键词
糖尿病合并肺结核
瑞格列奈
二甲双胍
Diabetes complicating with tuberculosis
Repaglinide
Metformin
