摘要
目的制备阿昔洛韦凝胶剂。方法以卡波普水凝胶为基质制备阿昔洛韦凝胶剂 ,采用紫外分光光度法进行含量测定 ,并进行稳定性和皮肤刺激性试验。结果阿昔洛韦在252nm有最大吸收峰 ,在4～16μg/ml浓度与吸收度线性关系良好 ,线性回归方程为C=17.7918A +0.2072,r=0.9996,平均回收率(n=5)为99.72%,RSD=0.42%。结论阿昔洛韦凝胶剂性质稳定 ,皮肤刺激性小 ,制备简单 ,易于质量控制 ,适用于医院配制。
Purpose: This article expounded on the preparation of Aciclovir gel. Method: The Carbomer hydrogel has been chosen as the basis for Aciclovir to make gel and the UV method was employed to determine the content. Besides, tests were carried out to investigate the stability and skin irritability. Results: Aciclovir showed the maximum absorbance at 252nm in solution and exhibited a good linear relationship with absorbance over the range of 4～16 μg/ml. It's regression equation is C=17.7918A+0.2072 (r=0.9996); the average recovery rate was 99.72%, RSD=0.42%(n=5). Conclusion: Aciclovir gel is stable and low in skin irritation with convenient usage as the advantage, easy to control, which means a reliable and proper preparation for the hospital.
出处
《天津药学》
2000年第2期66-66,共1页
Tianjin Pharmacy
