摘要
目的:通过观察头穴丛刺对慢性不可预见性应激模型大鼠行为学的改变,证明头穴丛刺对抑郁症的治疗作用。方法:24只3月龄健康雄性Wister大鼠,随机分为正常对照组、模型组、针刺组,每组8只;用慢性不可预见性轻度刺激结合孤养法造模,给予模型组和针刺组14天随机不同应激刺激,之后对针刺组进行针刺治疗,选"百会""神庭"及"四神聪",留针20 min,每日针刺1次,连续针刺治疗14天。在实验前1天、实验的第14天、21天、28天对大鼠进行测量体重、open-field评分及糖水消耗试验。结果:造模后14天模型组和针刺组大鼠体重、糖水消耗量明显低于正常对照组(P<0.05);造模后21天模型组大鼠体重、糖水消耗量均明显低于正常对照组(P<0.05),但针刺组大鼠仅体重明显低于正常对照组(P<0.05)而糖水消耗量虽低于正常对照组但不明显(P>0.05);造模第28天模型组大鼠体重、垂直运动、水平运动、糖水消耗量均明显低于针刺组(P<0.05),针刺组与正常对照组之间无显著差异。结论:头穴丛刺对慢性不可预见性应激结合孤养法制造抑郁症模型大鼠的行为学改变有治疗作用。
Objective：To observe the head point cluster-needling for chronic unpredictable stress model in rats’ behavioral changes,and to prove the head point cluster-needling for the treatment of depression.Methods：24 three-month-old male Wister rats were randomly divided into normal comparison group,model group,the head point cluster-needling group,eight rats in each group;with chronic unpredictable mild irritation with isolation to support law modeling,the model group and the head point cluster-needling group were given 14 days randomly different stress stimuli,followed by the head group of the cluster-needling acupuncture point treatment,choose ＂shenting＂,＂Baihui＂ and ＂Sishencong＂,leaving the needle 20min,once a day for 14 days.One day before the experiment,experiment on the 14th day,21st day,28th day measured body weight,open-field test scoring and sugar consumption.Results：Modeling the model group and 14 days after the first hole cluster-needling group were body weight,sugar consumption was significantly lower than that in the control group（P0.05）;modeling the first 28 days rats body weight,vertical movement,horizontal movement,sugar consumption were significantly lower than those in the first hole cluster-needling group（P〈0.05）,the first point cluster-needling group and normal control group,no significant differences.Conclusion：The first hole cluster-needling for chronic unpredictable stress method of manufacturing support with isolated rat model of depression,behavioral changes has a therapeutic effect.
出处
《针灸临床杂志》
2012年第6期47-49,共3页
Journal of Clinical Acupuncture and Moxibustion
基金
教育部"春晖计划"合作科研项目
编号:31 Y-43
关键词
头穴丛刺
慢性抑郁
open-field评分
糖水消耗试验
Head point cluster-needling
Chronic depression
Open-field test scoring
Sugar consumption experiment
