摘要
目的研究解郁逍遥汤对抑郁大鼠行为学表现的影响,分析其抗抑郁的可能机制。方法 32只SD大鼠随机分为空白对照组、模型组、用药组、生理盐水组,每组8只,通过慢性不可预见性应激刺激的方法建立抑郁大鼠模型。空白对照组和模型组正常饲养,用药组于造模第1天起给予浓度为0.93g/ml解郁逍遥汤浓缩剂10.5ml/kg灌胃,生理盐水组给予生理盐水2ml灌胃,两组均每日1次,共28天。分别于实验第0、21、28天对各组大鼠进行敞箱实验和糖水消耗试验。结果造模后第21、28天,模型组、用药组、生理盐水组大鼠水平、垂直活动次数和糖水消耗量均显著低于空白对照组(P<0.05或P<0.01)。用药组第28天大鼠水平、垂直活动次数和糖水消耗量明显高于模型组、生理盐水组(P<0.05);而模型组和生理盐水组之间差异无统计学意义(P>0.05)。各组大鼠第0、21、28天时总液体消耗量差异均无统计学意义(P>0.05)。结论解郁逍遥汤能改善抑郁大鼠的运动能力状态,并提升抑郁大鼠的欣快感,这可能是其治疗抑郁症的部分机制。
Objective To research the effect of Jieyu Xiaoyao Decoction （Depression-Resolving Free Wanderer Decoction） on the behavioral manifestations in depression rats and analyze the possible mechanism of anti-depression effect. Methods Totally 32 SD rats were randomized into the blank control group, model group, medication group and normal saline （NS） group, with 8 in each. The depression models were established with chronic unpredictable stress stimulation. The rats in the blank control group and model group were raised normally. The medication group was gavaged with 10.5 ml/kg of 0.93 g/ml Jieyu Xiaoyao Decoction once daily. The NS group was garaged with 2 ml NS once daily. The administration lasted for 28 days. The open field test and sucrose consumption test was conducted on the 0, 21st and 28th day of experiment. Results Comparing with the blank control group, the horizontal and vertical mobility and sucrose consumption were significantly decreased in the model group, medication group and NS group on the 21st and 28th day of experiment （P〈0.05 or P〈0.01）. The horizontal and vertical mobility and sucrose consumption in the medication group were significantly higher than that in the model group and NS group on the 28th day of experiment （P〈0.05）. There was no significant difference between the model group and NS group in the horizontal and vertical mobility and sucrose consumption （P〉0.05）. There was no significant difference between groups in the total liquid consumption on the 0, 21st and 28th day of experiment （P〉0.05）. Conclusion Jieyu Xiaoyao Decoction can improve the athletic ability and euphoria in depression rats, this might be part of the mechanism of its anti-depression effect.
出处
《中医杂志》
CSCD
北大核心
2013年第14期1230-1232,共3页
Journal of Traditional Chinese Medicine
基金
浙江省教育厅2010年度科研计划项目(Y201016842)
浙江省科技计划项目(2011C33003)
