摘要
目的探讨三叶因子3(TFF3)在浸润性乳癌组织中的表达及其与临床病理特征和预后关系。方法采用免疫组织化学PV-9005法,分别检测118例浸润性乳癌和30例正常乳腺组织中TFF3的表达,并对TFF3不同表达病人的临床病理特征及预后进行分析。结果 118例浸润性乳癌组织中TFF3蛋白的高表达率为44.1%(52/118),TFF3表达与病人的年龄、淋巴结是否转移及雌激素受体、孕激素受体、人表皮生长因子2蛋白的表达相关(χ2=4.11~5.84,P<0.05)。TFF3低表达病人的5年无进展生存期显著长于TFF3高表达者(χ2=5.92,P<0.05),5年的总生存期也显著延长(χ2=5.75,P<0.05)。单因素分析表明,肿瘤大小、淋巴结转移、TFF3蛋白表达、分期可以作为浸润性乳癌预后因素。多因素分析显示,肿瘤大小、淋巴结转移、TFF3蛋白表达是独立的预后因素。结论 TFF3的表达与浸润性乳癌病人的临床特征及预后有关,其高表达者预后较差。
Objective To investigate the expression of TFF3 in invasive breast cancer (IBC) and its correlation with clini- copathologic characteristics and prognosis. Methods Immunohistochemistry PV-9005 method was used to detect the expression of TFF3 in 118 cases of IBC and 30 cases of normal breast tissue. Patients with different TFF3 expressions were analyzd for their ciinicopathologic features and prognosis. Results In the 118 IBC patients, the expression of TFF3 was 44.1%(52/118), being correlated with patient's age, with or without lymph node metastasis, HER2, ER and PR expression (χ^2 --4. 11-5. 84,P/, 0.05). Patients with low expression of TFF3 had a longer 5 year-progression-free survival than that with high TFF3 expression (χ^2= 5.92 ,P〈0.05) so did as overall survival (χ^2 = 5.75, P〈0.05). Univariate analysis showed that the size of tumor, lymph node metastasis, TFF3 protein expression and stages could be factors contributing the prognosis; multivariate analysis indicated that the above factors were independent prognostic factors. Conclusion High expression of TFF3 is associated with clinical fea- tures and prognosis in IBC patients, for those with high expression of TFF3 will have a poor prognosis.
出处
《齐鲁医学杂志》
2012年第4期303-305,共3页
Medical Journal of Qilu
基金
山东省自然科学基金(Y2006C23)
关键词
三叶因子3
乳腺肿瘤
病理学
临床
预后
trefoil factor 3
breast neoplasms
pathology, clinical
prognosis