摘要
目的探讨氨溴索注射液对慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对患者血C-反应蛋白(CRP)及血沉(ESR)的影响。方法①按AECOPD诊断标准随机纳入80例AECOPD患者,分为氨溴索治疗组(40例)和对照组(40例);同时纳入30名稳定期COPD患者作为非治疗对照组。对照组患者主要给予抗感染及解痉平喘的基础治疗;治疗组患者在基础治疗的基础上给予氨溴索注射液(30mg)静滴,连续给予10天为1疗程。所有患者在治疗前后于清晨空腹抽取静脉血,测CRP及ESR水平。结果 AECOPD患者CRP、ESR水平显著高于稳定期COPD患者,P<0.01;与对照组比较,氨溴索治疗可显著降低CRP和ESR水平并可提高临床疗效,P<0.05。结论氨溴索注射液辅助治疗可显著降低AECOPD患者血清炎症因子水平,提高临床疗效。
Objective To explore the effects of Ambroxol to ESR and CRP in AECOPD patients and the clinical effects observed. Methods 80 AECOPD patients were divided into two group randomly, the Ambroxol group and the control group, each has 40 patients. And30 stable COPD patients were absorbed as non-therapy ＂control. The control group patients were given the base therapy, anti-infection and anti-spasmolysis. The Ambroxol group patients were given the Ambroxol injection 30 mg/d, intravenous drip, the therapy stage was 10 days. Before and after treatment, the blood were took and the CRP, ESR were detected, and the clinical effects was evaluated. Results Compared with the stable COPD patients, AECOPD patients had higher levels of CRP and ESR, and the Ambroxol treatment decreased the CRP and ESR levels significantly compared with the control group, and also has higher clinical effects, P 〈 0.05 versus control group. Conclusion Ambroxol treatment can decreased the CRP and ESR levels in AECOPD patients thus improved the clinical effects.
出处
《中国中医药现代远程教育》
2012年第9期68-70,共3页
Chinese Medicine Modern Distance Education of China
