摘要
目的探讨生化标志物缺血修饰白蛋白(IMA)、脂蛋白a[Lp(a)]、纤维蛋白原(Fib)及D-二聚体(DD)的联合检测对急性缺血性脑卒中(acute ischemic stroke,AIS)的诊断价值。方法检测59例急性缺血性脑卒中患者及30例正常对照者血清中IMA、Lp(a)和血浆中Fib、DD浓度,计算其阳性率进行比较分析。结果缺血性脑卒中患者IMA、Lp(a)、Fib、DD阳性率分别为64.4%(38/59)、42.4%(25/59)、49.2(29/59)%、40.7%(24/59),与正常对照(0%、0%、3.3%、0%)比较,均有统计学意义(P<0.01),IMA敏感性与其他3项相比差异均有统计学意义(P<0.01),该4项指标联合检测的敏感性为92.3%(55/59),均高于单项检测,差异有统计学意义(P<0.01)。结论在急性缺血性脑卒中的早期,IMA是一个比较灵敏的指标,IMA、Lp(a)、Fib、DD4项指标联合检测诊断急性缺血性脑卒中可明显提高敏感性,有较高的临床实用价值。
Objective To explore value of detection of biochemical markers ischemia modified albumin（IMA）,lipoprotein（a） ,fibrinogen（Fib） and the d-dimer（DD） in diagnosis of acute ischemic stroke（AIS）.Methods The levels of IMA,Lp（a）,Fib,DD and in 59 acute ischemic cerebral stroke patients and 30 normal controls were detected and analyzed.Results The positve rates of IMA,Lp（a）,Fib,DD in ischemic stroke patients were 64.4%（38/59）,42.4%（25/59）,49.2（29/59）%,40.7%（24/59）,and that were（0%,0%,3.3%,0%） in normal controls,all showed statistically significant difference（P〈0.01）,IMA sensitivity and three other than a difference were statistically significant differences（P〈0.01）.The sensitivity of 4 indicators was 92.3%（55/59） higher than the single detection,showing statistically significant differnce（P〈0.01）.Conclusion The IMA in early stage of acute ischemic stroke is a more sensitive indicator and joint detection of IMA,Lp（a）,Fib,DD 4 can enhance the sensitivity in diagnosis of acute ischemia stroke.
出处
《中国热带医学》
CAS
2012年第5期593-595,共3页
China Tropical Medicine
