摘要
目的评价缺血修饰清蛋白(IMA)对急性冠脉综合征(ACS)具有早期辅助诊断的意义。疾病类型不同其诊断意义亦不同。方法选择急性胸痛入院患者120例,其中急性心梗44例,心绞痛46例,非心源性胸痛30例。在胸痛发作5 h内采血做IMA实验,测定结果用ACB值(清蛋白钴结合能力,单位:U/ml)表示,观察IMA对各组疾病的诊断价值。另选30例急性心梗入院需溶栓治疗的患者,分别于溶栓前、溶栓开始后2,4,6,8,10,16,24 h采血做IMA实验,测定血清ACB值观察IMA对溶栓监测的意义。结果急性心梗组、心绞痛组患者血清IMA实验ACB值与正常对照组比较差异均有统计学意义(P<0.01),且心梗组患者血清IMA实验ACB值与心绞痛组比较差异有显著性(P<0.05)。在溶栓监测中各时间段的IMA实验ACB值比较差异无显著性(P>0.05)。结论IMA是诊断心肌缺血的早期指标,可用于ACS的早期诊断,且可明显提高对心绞痛早期诊断的灵敏性,但用于溶栓监测意义不大。
Objective To research the early auxiliary diagnostic value of ischemia modified albumin（IMA）for acute coronary syndrome. The disease type is different ,so the diagnostic significance is also different. Methods Selected 120 patients with acute chest pain in hospital ,which were classified as 44 acute myocardial infarction（AMI）patients,46 angina patients and 30 patients with non-ischemia chest pain（NICP）. IMA was detected in the serum within five hours of acute chest pain episode,and the determination was indicated with the value of ACB （albumin cobalt binding,Unit：U/ml）. The diagnostic values were observed for the different diseases. In addition,30 AMI patients which must be thrombolysed in therapy were measured in the serum of ACB with IMA test before thrombolysis and at 2,4,6,8,10,16,24 hours after thrombolysis ,and the significance was observed by measuring IMA. Results The serum levels of ACB with IMA test in AMI and angina patients were higher than in healthy controls （P〈0. 01）. As compared with AMI ,the serum level of ACB with IMA test was elevated in angina patients（P〈0.05）. The serum level of ACB in IMA test was not distinct in each stage monitoring thrombolysis. Conclusion IMA is a early diagnosis marker of ischemia,which may be useful to charaterise acute coronary syndrome （ACS）patients,and will improve the early diagnosis sensitivity of angina significantly. But IMA is not obvious useful for monitoring thrombolysis.
出处
《现代检验医学杂志》
CAS
2007年第3期23-25,共3页
Journal of Modern Laboratory Medicine
关键词
缺血修饰清蛋白
急性冠脉综合征
临床应用
ischemia modified albumin
acute coronary syndrome
clinical application
