摘要
1例33岁男性患者,因右眼被石头砸伤1 d入院,诊断为右眼钝挫伤、继发性青光眼。予以口服醋甲唑胺片25 mg,tid降眼压治疗,10 d后停药,行右眼巩膜下巩膜咬切术。术后第三日,患者出现面颈部皮疹,迅速波及全身,起初表现为红斑、丘疹,痒感明显,继而出现水疱、大疱、表皮松解剥脱,口腔、咽、眼黏膜受损、糜烂,伴渗出,同时存在高热、头痛、乏力等症状,考虑药源性Stevens-Johnson综合征,停用可疑药物,给予盐酸西替利嗪分散片、甲泼尼龙琥珀酸钠、人免疫球蛋白、盐酸去甲万古霉素等治疗,3周后,皮疹明显好转。
One 33-year-old male patient with right eye injured was hospitalized and diagnosed with secondary glaucoma. Methazolamide tablets （25 mg, tid） were given to lower intraocular pressure for 10 days before surgery. After operation for 3 days, rashes developed on his face and neck and quickly spread over the entire body, it initially manifested as erythema and papule, itching obviously, followed by blisters, bullae and epidermal necrolysis. At the same time, mucous membrane lesions of his mouth, pharynx and eyes progressed rapidly with exudation, accompanied by fever, headache, fatigue and other symptoms. Considering drug-induced Stevens-Johnson syndrome, suspected drugs were withdrawn, after treatment with cetirizine hydrochloride dispersible tablets, methylprednisolone sodium succinate, human immunoglobulin and norvancomycin hydrochloride and so on, the rashes were alleviated markedly 3 weeks later.
出处
《中国药物应用与监测》
CAS
2012年第3期179-181,共3页
Chinese Journal of Drug Application and Monitoring
